遵义医科大学学报2025，Vol.48Issue(7)：655-664,10.
3-苄基-5-O-葡萄糖苷环淫羊藿素改善大鼠球囊损伤后血管再狭窄作用及机制研究
The effect and mechanism of 3-benzyl-5-O-glucoside cycloicariin in improving vascular restenosis after balloon injury in rats
摘要
Abstract
Objective To investigate the effect and underlying mechanism of 3-benzyl-5-O-glucoside cycloicariin(designated as:lq210617)on vascular restenosis following balloon injury in rats.Methods The experimental ca-rotid artery balloon injury model was established in rats,which were randomly assigned to five groups:sham oper-ation group,model group and lq210617 treatment groups at doses of 10,20,40 mg/kg.HE staining was used to evaluate the morphological changes of common carotid artery.The expression of vascular smooth muscle cells contractile protein α-SMA,synthetic protein OPN,TLR4,IRAK-1,ERK1/2,p-ERK1/2 and PKC-s were detected by immunohistochemistry.Results The NIA,NIA/MA,and NIA/EELA values in 20 and 40 mg/kg lq210617 groups were significantly lower than those in the model group.α-SMA protein expression was significantly up-regulated and OPN protein expression was significantly down-regulated.the protein levels of TLR4,IRAK-1,ERK1/2,p-ERK1/2,and PKC-s was significantly down-regulated(P＜0.05).Conclusion lq210617 effectively suppressed the phenotypic switching of VSMCs in the balloon-injured region and improved vascular restenosis.The underly-ing mechanism involves the suppression of the TLR4/IRAK-1/ERK1/2signaling cascade activation.关键词
3-苄基-5-O-葡萄糖苷环淫羊藿素/血管再狭窄/球囊损伤/血管平滑肌细胞/表型转换/TLR4信号通路Key words
3-benzyl-5-O-glucoside cycloicariin/vascular restenosis/balloon injury/vascular smooth muscle cells/phenotypic transformation/TLR4 signaling pathway分类
医药卫生引用本文复制引用
袁乙丹,陈天旺,刘娟,黄波,徐尚福,李利生..3-苄基-5-O-葡萄糖苷环淫羊藿素改善大鼠球囊损伤后血管再狭窄作用及机制研究[J].遵义医科大学学报,2025,48(7):655-664,10.基金项目
贵州省科技计划项目[NO:黔科合基础-ZK(2023)一般500]. （2023）
