遵义医科大学学报2025，Vol.48Issue(7)：691-699,9.
心脏磁共振延迟强化定量评估二尖瓣病患心肌纤维化的临床价值
Clinical value of quantitative assessment of myocardial fibrosis using cardiac mag-netic resonance late gadolinium enhancement in patients with mitral valve disease
摘要
Abstract
Objective To explore the clinical value of cardiac magnetic resonance late gadolinium enhancement(CMR-LGE)in quantitative assessment of myocardial fibrosis in patients with mitral valve disease(MVD),and compare the relationship between fibrosis characteristics and cardiac function in patients with different types of MVD.Methods A total of 105 patients with MVD in West China Hospital of Sichuan University from January 2013 to November 2019 were enrolled.After screening,58 isolated patients[27 with mitral stenosis(MS)and 31 with mitral regurgitation(MR)]and 42 healthy controls were included.All participants underwent CMR-LGE examination,and Cvi42 post-processing software was used to evaluate the extent of left ventricular myocardial fi-brosis and analyze its segmental distribution and correlation with cardiac function and strain parameters.Results The incidence of LGE in patients with MR was significantly higher than that in patients with MS(x2=8.512,P=0.004).The extent of septal LGE(29.99±17.14)％was significantly greater than that of the anterior wall(22.70±17.75)％and lateral wall[(21.76±17.65)％,F=4.91,P=0.012].Left ventricular ejection frac-tion(LVEF)was significantly lower in severe LGE group than in mild/moderate group,and LGE volume ratio showed significant negative correlation with LVEF(r=-0.69,P=0.01).The LGE group showed increased left ventricular end-diastolic volume[(207.05±82.74)ml vs(167.42±73.02)ml,F=5.26,P=0.023],with decreased myocardial mass and remodeling index compared with non-LGE group.The global and mid-ventricular peak radial strain and circumferential strain were significantly reduced in severe LGE group compared with mild/moderate group(P＜0.05).Conclusion CMR-LGE can quantify the distribution and extent of myocardial fibro-sis in patients with MVD,providing important clinical value for assessing disease severity and prognosis.关键词
心脏磁共振/延迟强化/二尖瓣病变/心肌纤维化/心功能Key words
cardiac magnetic resonance/late gadolinium enhancement/mitral valve disease/myocardial fi-brosis/cardiac function分类
医药卫生引用本文复制引用
余洪,杨志刚..心脏磁共振延迟强化定量评估二尖瓣病患心肌纤维化的临床价值[J].遵义医科大学学报,2025,48(7):691-699,9.基金项目
国家自然科学基金面上项目(NO:82371925) （NO:82371925）
遵义市科技计划项目[NO:遵市科合HZ字(2022)259]. （2022）
