中药与临床2025，Vol.16Issue(4)：20-26,36,8.
三味绿矾含漱剂的制备及质量评价研究
Study on the preparation and quality evaluation of three-flavored Lvfan gargle
摘要
Abstract
Objective:To study the preparation process of three-flavored Lvfan gargle,and evaluate its quality.Methods:The optimal parameters of extraction were obtained by single-factor screening of extraction temperature,extraction time and water addition in extracting Shanfanye and Hezi.Orthogonal test was utilized to obtain the optimal solution ratio of the gargle.Finally,the quality of the prepared gargle was evaluated,including performance,physical and chemical indexes,and prescription chemical composition.Re-sults:The optimal extraction conditions for Hezi and Shanfanye were material-liquid ratio of 1∶10(g·mL-1),extraction temperature of 60 ℃,and extraction time of 4 h.The optimal formulation ratio for the gargle was 50%mixed herbal extract,15%ethanol,7.5%glycerin,0.02%ethylparaben,0.5%sodium bisulfite,1%tween-80,with pH adjusted to 6-7.The prepared three-flavored Lvfan gargle exhibited a cool taste,aromatic odor,uniform and clear solution,and met industry standards for stability and pH.LC-MS/MS analysis identified 46 compounds in the formulation,primarily including tannins,phenolic acids,flavonoids,and triterpenoids.Con-clusion:Converting three-flavored Lvfan from a powder to a gargle significantly enhances patient convenience while ensuring quality.This study establishes the chemical basis of Sanwei Lvfan formulations,providing scientific support for future large-scale production and quality control.关键词
三味绿矾/含漱剂/制备工艺/质量评价/成分分析/口腔溃疡Key words
Sanwei Lvfan/gargle/preparation process/quality evaluation/component analysis/mouth ulcers分类
医药卫生引用本文复制引用
徐慧源,杨宇,益西拉姆,黄勤挽..三味绿矾含漱剂的制备及质量评价研究[J].中药与临床,2025,16(4):20-26,36,8.基金项目
西藏自治区教育厅藏医药"十四五"规划内涵建设项目(2022ZYYGH05) （2022ZYYGH05）
