中医药学报2025，Vol.53Issue(8)：14-18,5.DOI:10.19664/j.cnki.1002-2392.250158
刺玫果总黄酮对高尿酸血症的影响
Effects of Total Flavonoids from Dahurian Rose Fruit on Hyperuricemia
摘要
Abstract
Objective:By exploring the effect of total flavonoids from Dahurian Rose Fruit on hyperuricemia induced by potassium oxonate in mice,the anti hyperuricemia effect of total flavonoids from Rosa rugosa was verified.Methods:Sixty SPF-grade mice were randomly divided into six groups:blank control group,model group,positive drug group,and Dahurian Rose Fruit high-,medium-,and low-dose groups,with 10 mice per group.Except for the blank control group,all groups received 400 μL of 500 mg/kg potassium oxonate by gavage to establish hyperuricemia models.After 1-hour intervals,treatment groups received 400 μL of Dahurian Rose Fruit extract(1 g/mL,0.6 g/mL,or 0.3 g/mL)or 5 mg/kg allopurinol suspension,while the blank and model groups received 400 μL PBS solution by gavage once daily for 7 consecutive days.Behavioral status of the mice,organ indices,serum uric acid levels,hepatic xanthine oxidase activity,and renal histopathology(HE staining)were compared among groups.Results:All Dahurian Rose Fruit dose groups significantly reduced serum uric acid levels(P<0.05,P<0.01)and inhibited hepatic xanthine oxidase activity(P<0.05,P<0.01),while ameliorating renal tissue damage induced by hyperuricemia,demonstrating renal protective effects.Conclusion:Dahurian Rose Fruit effectively lowers uric acid and alleviates hyperuricemia-induced hepatic and renal damage.This study provides scientific evidence for the development and utilization of Dahurian Rose Fruit.关键词
刺玫果/总黄酮/高尿酸血症/黄嘌呤氧化酶Key words
Dahurian Rose Fruit/Total flavonoids/Hyperuricemia/Xanthine oxidase分类
医药卫生引用本文复制引用
马天宇,肖智杰,段卓然,常梓睿,毛宏宇,孟永海,翟春梅..刺玫果总黄酮对高尿酸血症的影响[J].中医药学报,2025,53(8):14-18,5.基金项目
黑龙江省博士后科研启动金资助项目(LBH-Q15137) （LBH-Q15137）
哈尔滨市科技创新人才研究专项资金项目(2017RAQXJ125) （2017RAQXJ125）
黑龙江中医药大学研究生创新科研项目(2022yjscx055) （2022yjscx055）
