福建农业学报2025，Vol.40Issue(4)：396-405,10.DOI:10.19303/j.issn.1008-0384.2025.04.009
基于非靶向代谢组学探析骏眉红茶对血清代谢的影响
Effects of Junmei Black Tea on Serum Metabolism:An Untargeted Metabolomics Analysis
摘要
Abstract
[Objective]Effect of Junmei black tea extract on serum metabolism in mice was investigated based upon the nontargeted metabolomics for potential pharmaceutical applications.[Method]Aqueous extract of Junmei black tea was freeze-dried to be orally administered to 6-week-old C57BL/6 SPF male mice(n=5)at 450 mg·kg-1·d-1 for 8 consecutive weeks,along with control fed with distilled water.Serum samples collected from the mice after the feeding were centrifuged for a nontargeted metabolomics analysis.The serum metabolites were clustered,differentiated,and subjected to KEGG and MSEA enrichment analyses to determine possible interventions by the tea extract.[Result]After the feeding,3 599 differential metabolites were detected in serum of the mice.Of which,576 were significantly different(P＜0.05),and 149 signaling pathways significantly different on the principal components,clustering,and KEGG enrichment(P＜0.05).The top 20 differential metabolites and signaling pathways closely related to body lipid metabolism,neural excitation regulation,anti-fatigue regulation,inflammation regulation,cardiovascular disease,etc.[Conclusion]Oral administration of Junmei black tea extract significantly affected the serum metabolites in mice.Since those metabolites involve functions,such as lipid metabolism,nervous system regulation,anti-fatigue,inflammatory immunity,and cardiovascular disease,the potential of the tea in regulating blood metabolism seemed to exist.关键词
骏眉红茶/代谢组学/茶溶物/脂代谢Key words
Junmei black tea/metabolomics/tea extract/lipid metabolism分类
农业科技引用本文复制引用
和书宇,谢秋容,李加鹏..基于非靶向代谢组学探析骏眉红茶对血清代谢的影响[J].福建农业学报,2025,40(4):396-405,10.基金项目
福建中医药大学重大科技创新"揭榜挂帅"专项(XJB2022009) （XJB2022009）
福建省自然科学基金项目(2023J01850) （2023J01850）
