法医学杂志2025，Vol.41Issue(2)：120-126,7.DOI:10.12116/j.issn.1004-5619.2024.440404
阿霉素心脏毒性机制研究及法医学应用
Research on Doxorubicin-Induced Cardiotoxicity Mechanism and Its Forensic Ap-plication
摘要
Abstract
Doxorubicin is a commonly used antitumor drug for the treatment of various cancers.How-ever,its clinical application is greatly restricted by its severe cardiotoxicity.At present,doxorubicin-induced cardiotoxicity is categorized into acute and chronic forms,depending on the dosage and dura-tion of exposure,which may eventually lead to the occurrence of heart failure.The pathogenesis of doxorubicin cardiotoxicity is associated with oxidative stress,mitochondrial damage,calcium overload,dysregulation of autophagy,and apoptosis.In forensic medical practice,cases of poisoning or even car-diac death caused by doxorubicin showed no obvious changes in cardiac morphology through routine forensic pathological examinations.The paper aims to summarize the research on the mechanisms of action of doxorubicin-induced cardiotoxicity in recent years,analyze and discuss the possible pathways of cardiomyocyte injury caused by doxorubicin,and provide references for research on the mechanisms of doxorubicin-induced cardiotoxicity and forensic application.关键词
法医病理学/法医毒理学/阿霉素/心脏毒性/药物作用机制/综述Key words
forensic pathology/forensic toxicology/doxorubicin/cardiotoxicity/mechanism of drug ac-tion/review分类
医药卫生引用本文复制引用
张帅,许弘飞,张志湘,王盈,朱少华..阿霉素心脏毒性机制研究及法医学应用[J].法医学杂志,2025,41(2):120-126,7.基金项目
国家自然科学基金资助项目(82171871) （82171871）
