法医学杂志2025，Vol.41Issue(2)：160-167,8.DOI:10.12116/j.issn.1004-5619.2024.340303
美沙酮相关中毒案例分析
Analysis of Methadone-Related Poisoning Cases
摘要
Abstract
Objective To analyze the characteristics of methadone-related poisoning cases and provide a reference for forensic identification.Methods A total of 71 cases of methadone-related poisoning re-ported from 1998 to 2023 in China and 26 cases of methadone-related deaths reported from 2013 to 2018 in Italy were retrieved from databases including PubMed,Wanfang and CNKI.The general infor-mation,forensic pathological and toxicological characteristics were analyzed.Results Among the 71 methadone-related poisoning cases in China,there were 54 cases(76.06%)of poisoning without death and 17 cases(23.94%)of death from poisoning.There were 54 male cases(76.06%),and 51 cases(71.83%)aged 19 to 39 years old.There were 35 cases(49.30%)of poisoning caused by methadone alone,and 32 cases(45.07%)were poisoning caused by methadone combined with other substances or drugs including heroin and benzodiazepines.Most of the poisoned showed coma,respiratory depres-sion and miosis.Signs of asphyxia were often found by autopsy.The mass concentration of methadone detected in the blood of 6 deceased ranged from 0.112 to 3.000 mg/L.Among the 26 methadone-related deaths in Italy,22 cases were male(84.62%).There were 6 cases(23.08%)caused by methadone alone,and 20 cases(76.92%)died from methadone combined with other substances or drugs.The mass concentration of methadone in blood ranged from 0.181 to 4.059 mg/L.Conclusion The propor-tions of poisoning cases caused by methadone alone and methadone combined with other substances or drugs are comparable in China.The majority of deceased caused by methadone poisoning shows typi-cal triad of coma,respiratory depression and miosis,which helps forensic experts determine the cause of death related to methadone.Additionally,it is necessary to increase the routine testing of the con-centration of methadone and its combined substances or drugs in deceased,and collect data for the in-terpretation of the results of related cases.关键词
法医病理学/法医毒理学/美沙酮/中毒/死因分析/案例分析Key words
forensic pathology/forensic toxicology/methadone/poisoning/analysis of death cause/cases analysis分类
医药卫生引用本文复制引用
李泽绮,邢蕾,张慧鸽,何丽柔,张佳奕,汪佳琪,刘世豪,杨卫红..美沙酮相关中毒案例分析[J].法医学杂志,2025,41(2):160-167,8.基金项目
河南省科技厅项目(222102310186) （222102310186）
郑州大学课程思政教育教学改革示范课程重点项目(2022ZZUKCSZ044) （2022ZZUKCSZ044）
