口腔疾病防治2025，Vol.33Issue(8)：672-679,8.DOI:10.12016/j.issn.2096-1456.202550044
牙龈上皮细胞在牙周稳态维持中的作用及机制
The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis
摘要
Abstract
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier,the extracellular matrix of soft tissues,the bone coupling system,and immune responses within the periodontal region.Gin-gival epithelial cells are primarily composed of keratinocytes and a small proportion of non-keratinocytes,and they are integral to the formation of the gingival epithelial barrier.This epithelial barrier plays a fundamental role in defending against pathogens,exogenous substances,and mechanical stress.This study aims to explore the intrinsic connections be-tween gingival epithelial cells and periodontal homeostasis.Research has shown that gingival epithelial cells participate in maintaining periodontal homeostasis through multiple pathways:① gingival epithelial cells respond to the inflamma-tory environment by undergoing proliferation,migration,epithelial-mesenchymal transition,and forming apoptosis-mediated neutrophil extracellular traps;② when gingival inflammation damages the epithelial barrier,lipopolysaccha-rides cannot be easily removed,and gingival epithelial cells play a defensive role by activating innate immune re-sponses;③ the interactions of gingival epithelial cells with oral microbiota and immune cells are essential for maintain-ing periodontal homeostasis.Thus,gingival epithelial cells are closely associated with periodontal homeostasis.How-ever,the crucial role and mechanisms of gingival epithelial cells in the maintenance of periodontal homeostasis are not clear,which provides novel insights for the research of periodontal homeostatic medicine.关键词
牙龈上皮细胞/牙周稳态/上皮屏障/上皮间充质转化/细胞凋亡/免疫反应/口腔微生物/免疫细胞Key words
gingival epithelial cells/periodontal homeostasis/epithelium barrier/epithelial-mesenchymal transition/apoptosis/immune responses/oral microorganisms/immune cell分类
医药卫生引用本文复制引用
王晓,吴雅洁,苏志飞,李继遥..牙龈上皮细胞在牙周稳态维持中的作用及机制[J].口腔疾病防治,2025,33(8):672-679,8.基金项目
国家自然科学基金项目(81991501,81991500) （81991501,81991500）
四川省自然科学基金项目(2024NSFSC1584) This study was supported by grants from the National Natural Science Foundation of China(No.81991501,No.81991500)and the Natural Sciences Foundation of Sichuan Province(No.2024NSFSC1584). （2024NSFSC1584）
