口腔疾病防治2025，Vol.33Issue(8)：699-708,10.DOI:10.12016/j.issn.2096-1456.202550077
纳米抗菌材料在根管治疗中的研究进展
Research progress on nano-antimicrobial materials in root canal therapy
摘要
Abstract
The efficacy of root canal therapy,as a core intervention for endodontic and periapical diseases,is highly dependent on the effectiveness of antimicrobial drugs.Although traditional drugs such as calcium hydroxide,chlorhexi-dine,and antibiotic pastes commonly used in the clinic play a role in preventing and controlling infections,they have obvious limitations.These drugs influence the mechanical properties of dentin,insufficiently solubilize necrotic tissues,and are susceptible to bacterial resistance,which makes achieving the desired effectiveness and safety difficult.Tradi-tional macromolecular root canal drugs also face the challenge of the complexity of the root canal system.With the rapid development of material science in recent years,new antimicrobial agents have emerged.Metallic nanomaterials such as silver nanoparticles and zinc oxide nanoparticles are widely used in the medical field due to their unique physi-cochemical properties and superior antimicrobial properties.Chitosan nanoparticles have superior biosafety,calcium hy-droxide nanoparticles compensate for the limitations of traditional calcium hydroxide formulations,and quaternary am-monium polyethyleneimine nanoparticles can confer antimicrobial properties to existing oral materials.Novel antimicro-bial nanoparticles using nano-delivery systems,such as mesoporous calcium silicate and mesoporous silica,carry anti-microbial molecules with significant advantages in terms of anti-biofilm,biosafety,and promotion of tissue repair.Fur-ther,these agents reduce drug resistance,which improves prospects for application compared to traditional root canal disinfection drugs.The breakthrough of nanotechnology provides a novel direction for the innovation of root canal treat-ment drugs.Therefore,this paper reviews the research progress of nano-antimicrobial materials in root canal therapy.关键词
牙髓病/根尖周病/根管治疗/抗菌纳米颗粒/金属纳米颗粒/银纳米颗粒/氧化锌纳米颗粒/壳聚糖纳米颗粒/氢氧化钙纳米颗粒/季铵聚乙烯亚胺纳米颗粒/纳米递送系统/介孔硅酸钙纳米颗粒/介孔二氧化硅纳米颗粒分类
医药卫生引用本文复制引用
王依依,秦璐,贾言敏,杜旭硕,刘飞,王素苹..纳米抗菌材料在根管治疗中的研究进展[J].口腔疾病防治,2025,33(8):699-708,10.基金项目
河南省医学科技攻关计划省部共建重点项目(SBGJ202102162),河南省教育厅高等学校重点科研项目(22A320006) The study was supported by Henan Provincial Medical Science and Technology Research Plan Provincial Key Project(No.SBGJ202102162) （SBGJ202102162）
Henan Provincial Department of Education Key Scientific Research Project of Higher Education Institutions(No.22A320006). （No.22A320006）
