西部中医药2025，Vol.38Issue(6)：13-17,5.DOI:10.12174/j.issn.2096-9600.2025.06.03
推拿对坐骨神经损伤模型大鼠疼痛、炎性介质及腓肠肌的影响
Effects of Massage on Pain,Inflammatory Mediators and Gastrocnemius Muscle in Chronic Constriction Injury Rat Models
摘要
Abstract
Objective:To explore the effects of massage on pain behavior,plasma inflammatory mediators and gastrocnemius muscle in chronic constriction injury(CCI)rat models.Methods:A total of 32 male SD rats were randomized into four groups,the model group and the massage group were prepared into CCI models through the method of light puncture of rat sciatic nerve with catgut.The blank group didn't accept any surgical procedure,and sham operation group was not ligated with catgut,and the rest procedures were the same as CCI modeling.After the intervention,to observe surgical behavior including PWT and PWL,the recovery rate of gastrocnemius muscle wet weight,myocyte morphology,and the expressions of IL-1β,IL-6 and TNF-α as well as 5-HT in the four groups.Results:Compared with the blank group,PWT and PWL,the recovery rate of gastrocnemius muscle wet weight,sectional area of myocytes in the model group were reduced at different time points(P＜0.001),the levels of plasma IL-1β,IL-6 and TNF-α as well as 5-HT were increased(P＜0.001);The difference had no statistical meaning when the indexes of sham operation group were compared with these of the blank group(P＞0.05);compared with the model group,PWT and PWL,the recovery rate of gastrocnemius muscle wet weight,sectional area of myocytes were lifted in the massage group(P＜0.05),the levels of plasma IL-1β,IL-6 and TNF-α as well as 5-HT were decreased(P＜0.05).Conclusion:Massage could relieve the pain in CCI rat models,and its mechanism might be related to restraining the release of inflammatory mediators including IL-1β,IL-6 and TNF-α,5-HT,and alleviating peripheral inflammatory response.关键词
坐骨神经损伤/疼痛/炎性介质/腓肠肌/推拿Key words
chronic constriction injury/pain/inflammatory mediators/gastrocnemius muscle/massage分类
医药卫生引用本文复制引用
吴志伟,周鑫,宋朋飞,程艳彬,房敏..推拿对坐骨神经损伤模型大鼠疼痛、炎性介质及腓肠肌的影响[J].西部中医药,2025,38(6):13-17,5.基金项目
国家自然科学基金(82205302,82030121) （82205302,82030121）
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202008) （ZYYCXTD-C-202008）
上海市青年科技英才扬帆计划(20YF1450900) （20YF1450900）
上海中医药大学杏林中青年人才项目(上中医人字[2020]23号) （上中医人字[2020]23号）
岳阳医院院级基金(2021yygq03). （2021yygq03）
