西部中医药2025，Vol.38Issue(6)：17-21,5.DOI:10.12174/j.issn.2096-9600.2025.06.04
黄连解毒汤对热体变应性鼻炎大鼠骨髓干细胞增殖的影响
Effects of Huanglian Detoxification Decoction on Proliferation of Bone Marrow Stem Cells in Heat Constitutional Type Rats with Allergic Rhinitis
摘要
Abstract
Objective:To study the effects of Huanglian detoxification decoction on the proliferation of bone marrow mesenchymal stem cells(BMSCs)and bone endothelial progenitor cells(BEPCs)in heat constitutional type rats with allergic rhinitis(AR).Methods:After depulicating hereditary heat constitutional type rats with AR,48 rat models were allocated to heat constitution group without intervention and heat constitution group with intervention,half of male and half of female,24 cases in each group.Heat constitution group with intervention was drenched with Huanglian detoxification decoction since the second day of modeling,for seven days continuously;heat constitution group without intervention remained unhandled.The scores of nasal symptoms of the two groups were evaluated on the zero,first,third and seventh day of intervention,and the contents of BMSCs and BEPCs were detected after taking the tissues.Results:After the intervention,compared with the same group on the zero day,the scores of nasal symptoms in heat constitution group with intervention were reduced on the third and seventh day(P＜0.05);compared with heat constitution group without intervention at the same time point,the reduction in the scores of nasal symptoms in heat constitution group with intervention was significant on the seventh day(P＜0.05);compared with the same group on the zero day,the decrease in the expressions of BMSCs and BEPCs was evident in heat constitution group without intervention on the first,third and seventh day(P＜0.05),the increase in the expressions of BMSCs was obvious in heat constitution group with intervention on the seventh day(P＜0.05),while the expressions of BEPCs were lowered(P＜0.05).The comparison with constitution group without intervention at the same time point showed that the levels of BMSCs and BEPCs were elevated in heat constitution group without intervention on the third and seventh day(P＜0.05).Conclusion:Huanglian detoxification decoction could promote the proliferation of BMSCs and BEPCs,and effectively alleviate the symptoms of AR.关键词
变应性鼻炎/骨髓间充质干细胞/骨髓内皮祖细胞/增殖/黄连解毒汤Key words
allergic rhinitis/bone marrow mesenchymal stem cells/bone endothelial progenitor cells/proliferation/Huanglian detoxification decoction分类
医药卫生引用本文复制引用
蔡蔚然,张弢,沈斌,忻耀杰,滕磊..黄连解毒汤对热体变应性鼻炎大鼠骨髓干细胞增殖的影响[J].西部中医药,2025,38(6):17-21,5.基金项目
国家自然科学基金面上项目(81574033,82174447). （81574033,82174447）
