神经损伤与功能重建2025，Vol.20Issue(8)：465-469,5.DOI:10.16780/j.cnki.sjssgncj.20230714
脑源性神经营养因子亚型改善认知功能障碍研究进展
The Role and Mechanism of Brain-derived Neurotrophic Factor Subtype in Improving Cognitive Impairment
摘要
Abstract
Patients with cognitive dysfunction are often accompanied by neuropathy,in which brain-derived neurotrophic factor(BDNF)plays an important role in the growth and survival of neurons.Current researches focus on its effect of improving motor dysfunction,but there is increasing evidence that BDNF also plays an important regulatory role in cognitive function.Nevertheless,most of the existing researches are limited to observing the change of its expression level,and fail to deeply explore the mechanism behind this change.This review summarizes the research progress of BDNF subtypes and their functions,and analyzes the relationship between BDNF and cognitive dysfunction from the aspects of learning and memory ability,synaptic structural plasticity and neurotransmitters,in order to provide reference for the basic research and clinical intervention of cognitive dysfunction.关键词
认知功能障碍/脑源性神经营养因子/突触可塑性/神经递质Key words
cognitive impairment/brain-derived neurotrophic factor/synaptic plasticity/neurotransmitter分类
医药卫生引用本文复制引用
熊紫怡,刘伟,门伟业,张鸿宇,宋文君,英振昊..脑源性神经营养因子亚型改善认知功能障碍研究进展[J].神经损伤与功能重建,2025,20(8):465-469,5.基金项目
国家自然科学基金项目(滋补肝肾方调控脊髓m-BDNF/TrkB和pro-BDNF/p75NTR/sortilin平衡促进脑梗死皮质脊髓束重塑作用机制研究,No.82174367) （滋补肝肾方调控脊髓m-BDNF/TrkB和pro-BDNF/p75NTR/sortilin平衡促进脑梗死皮质脊髓束重塑作用机制研究,No.82174367）
山东省中医药科技项目(Slit-Robo信号通路在针刺促进MCAO大鼠神经功能重塑中的作用及机制研究,No.2020M003) （Slit-Robo信号通路在针刺促进MCAO大鼠神经功能重塑中的作用及机制研究,No.2020M003）
基于中医髓认知的神经再生机制及中医神经康复策略研究青年科研创新团队(针药结合调控脂代谢促进MCAO大鼠神经功能重塑作用机制研究,No.28) （针药结合调控脂代谢促进MCAO大鼠神经功能重塑作用机制研究,No.28）
