神经损伤与功能重建2025，Vol.20Issue(8)：470-473,496,5.DOI:10.16780/j.cnki.sjssgncj.20240390
星形胶质细胞在睡眠剥夺引发认知功能障碍中的作用机制研究进展
Mechanisms of Astrocytes in Sleep Deprivation Triggered Cognitive Impairment:A Review
摘要
Abstract
Insufficient sleep duration,referred to as sleep deprivation,can be caused by various triggers such as poor lifestyle habits,disease,or environmental factors,which can directly lead to impaired cognitive function.Research suggests that the impact of sleep deprivation on astrocytes may be a key node leading to cognitive dysfunction.The mechanisms by which astrocytes exert their effects has not yet been fully elucidated;however,they may involve multiple pathways including participation in synaptic plasticity,β-amyloid deposition,accumulation of excitatory neurotransmitters,oxidative stress,and immune inflammation.This review summarizes researches over the past decade related to astrocytes,sleep deprivation,and cognitive impairments.It consolidates the relevant influencing factors and mechanistic pathways,outlines the interactive relationships of the pathogenic mechanisms,and explores potential therapeutic strategies.The aim is to provide a more comprehensive perspective on the role of astrocytes in sleep deprivation,promoting further development in related research fields and providing a theoretical basis for the development of new treatment methods and intervention measures.关键词
星形胶质细胞/睡眠剥夺/认知功能障碍/β-淀粉样蛋白/α7烟碱型乙酰胆碱受体Key words
astrocytes/sleep deprivation/cognitive impairment/amyloid β-protein/α7 nicotinic acetylcholine receptors分类
医药卫生引用本文复制引用
严子昂,田其,李明昌..星形胶质细胞在睡眠剥夺引发认知功能障碍中的作用机制研究进展[J].神经损伤与功能重建,2025,20(8):470-473,496,5.基金项目
国家自然科学基金项目(BAP1介导H2B去泛素化抑制System Xc-在蛛网膜下腔出血神经元铁死亡中的作用和机制研究,No.82172173) （BAP1介导H2B去泛素化抑制System Xc-在蛛网膜下腔出血神经元铁死亡中的作用和机制研究,No.82172173）
