神经损伤与功能重建2025，Vol.20Issue(8)：474-477,482,5.DOI:10.16780/j.cnki.sjssgncj.20250052
血管性认知障碍与神经血管慢性低灌注损伤的机制研究进展
Research Progress on the Mechanisms of Vascular Cognitive Impairment and Neurovascular Chronic Hypoperfusion Injury
摘要
Abstract
Chronic cerebral hypoperfusion(CCH)is a significant cause and pathogenesis of vascular cognitive impairment(VCI).The neurovascular unit(NVU),as the basic functional unit of the central nervous system,re-sponds to prolonged cerebral hypoperfusion through individual and cross-communication among neurovascular cells.Neuroinflammation is amplified in a cascade,leading to irreversible brain tissue damage and cognitive dys-function.The screening of early biological and imaging markers of CCH provides the possibility for early identi-fication and intervention of VCI.This article reviews the potential mechanisms by which CCH induces VCI and the expression of early related markers,aiming to provide a theoretical basis for the early screening,diagnosis,and intervention of VCI.关键词
慢性脑低灌注/血管性认知障碍/神经血管/机制/标志物Key words
chronic cerebral hypoperfusion/vascular cognitive impairment/neurovascular unit/mechanism/biomarkers分类
医药卫生引用本文复制引用
江珊,陆征宇..血管性认知障碍与神经血管慢性低灌注损伤的机制研究进展[J].神经损伤与功能重建,2025,20(8):474-477,482,5.基金项目
国家自然科学基金项目(聚焦突触可塑性探索化痰开窍法调节轴突线粒体自噬修复慢性脑低灌注损伤的机制,No.82274431) （聚焦突触可塑性探索化痰开窍法调节轴突线粒体自噬修复慢性脑低灌注损伤的机制,No.82274431）
上海中医药大学附属曙光医院四明基金(芪龙祛瘀合剂抗脑梗后慢性脑低灌注损伤的初步研究探讨,No.SGKY-202414) （芪龙祛瘀合剂抗脑梗后慢性脑低灌注损伤的初步研究探讨,No.SGKY-202414）
