神经损伤与功能重建2025，Vol.20Issue(8)：478-482,5.DOI:10.16780/j.cnki.sjssgncj.20241366
卒中后认知障碍的预测指标的研究进展
Research Progress on Predictive Indicators of Post-Stroke Cognitive Impairment
摘要
Abstract
Stroke is a leading cause of death and disability in adults worldwide.Although advancements in stroke treatment have significantly reduced mortality and disability rates,post-stroke cognitive impairment(PSCI)remains a common complication that severely impacts patients'quality of life.PSCI is characterized by impairments in memory,abstract thinking,visuospatial abilities,and personality changes,and is closely linked to survival rates.Despite extensive research aimed at identifying early warning biomarkers for PSCI,these findings have not yet been translated into clinical practice,potentially causing patients to miss optimal treatment windows.Therefore,early identification and intervention of PSCI should become an integral part of stroke management.This review summarizes the latest research progress on PSCI,discussing the potential of imaging tests,fluid biomarkers,and neurological function assessments.Future research should focus on com-bining imaging with artificial intelligence to identify cognitive impairment risks at an early stage,explore pre-cise diagnostic indicators,and develop clinically applicable PSCI risk prediction models.Promoting early warning,early diagnosis,and early treatment will provide new ideas for the clinical management of PSCI.关键词
卒中后认知障碍/预测指标/预测模型Key words
post-stroke cognitive impairment/predictive indicators/predictive model分类
医药卫生引用本文复制引用
李峻豪,罗钰鼎,段川西,熊海,王建..卒中后认知障碍的预测指标的研究进展[J].神经损伤与功能重建,2025,20(8):478-482,5.基金项目
四川省卫健委临床研究专项基金(急性大血管闭塞性卒中后认知障碍诊断预测模型的临床研究,No.23LCYJ034) （急性大血管闭塞性卒中后认知障碍诊断预测模型的临床研究,No.23LCYJ034）
成都医学院—雅安市人民医院临床科学研究基金(川西高原地区急性大血管闭塞型脑卒中防治关键技术和人工智能预测模型的研究,No.24LHLNYX1-38) （川西高原地区急性大血管闭塞型脑卒中防治关键技术和人工智能预测模型的研究,No.24LHLNYX1-38）
四川省医学科技创新研究会专项基金(探讨红景天苷经PI3K/AKT通路对脑无复流现象中周细胞凋亡的保护作用,No.YCH-KY-YCZD2024-037) （探讨红景天苷经PI3K/AKT通路对脑无复流现象中周细胞凋亡的保护作用,No.YCH-KY-YCZD2024-037）
四川省自然科学基金面上项目(基于PI3K/AKT和NF-κB信号通路探讨红景天苷对脑缺血/再灌注后无复流现象中周细胞凋亡的调控机制,No.2025ZNSFSC0618) （基于PI3K/AKT和NF-κB信号通路探讨红景天苷对脑缺血/再灌注后无复流现象中周细胞凋亡的调控机制,No.2025ZNSFSC0618）
