神经损伤与功能重建2025，Vol.20Issue(8)：483-486,490,5.DOI:10.16780/j.cnki.sjssgncj.20230648
蛋白质乳酸化修饰及其在神经系统疾病中的研究进展
Lactylation Modification and Its Research Progress in Neurological Disorders
摘要
Abstract
Lactylation is a recently discovered post-translational modification that occurs on both histone and non-histone proteins.Since the identification of lactylation modification sites on core histones by Zhang et al.in 2019,numerous researchers have shifted their focus towards exploring the relationship between lactylation and neurological disorders,aiming to regulate lactylation to improve the prognosis of central nervous system diseases.This article provides an overview of the associations and regulatory mechanisms between lactylation and various neurological disorders,such as Alzheimer's disease,cerebral ischemia reperfusion injury and hypoxic-ischemic encephalopathy.By gaining a deeper insight into the mechanistic roles of lactylation in different neurological diseases,valuable references are provided for future research endeavors.关键词
翻译后修饰/乳酸化修饰/神经系统性疾病Key words
post-translational modifications/lactylation/neurological diseases分类
医药卫生引用本文复制引用
齐雪,王伟,李亚男,王苏,高文蔚,赵博..蛋白质乳酸化修饰及其在神经系统疾病中的研究进展[J].神经损伤与功能重建,2025,20(8):483-486,490,5.基金项目
国家自然科学基金项目(cGAS-STING通路调控NCOA4介导的铁自噬在脑缺血再灌注损伤中的作用,No.82102295) （cGAS-STING通路调控NCOA4介导的铁自噬在脑缺血再灌注损伤中的作用,No.82102295）
