中医药导报2025，Vol.31Issue(7)：51-56,90,7.DOI:10.13862/j.cn43-1446/r.2025.07.008
基于多指标成分定量、化学计量学及加权TOPSIS模型的不同产地乌梅质量差异评价
Quality Evaluation of Wumei(Mume Fructus)from Different Origins Based on Multi-Component Quantification,Chemometrics,and Weighted TOPSIS Model
摘要
Abstract
Objective:To compare the multi-component contents of Wumei(mume fructus)from different producing areas and establish a quality evaluation system integrating chemometrics and weighted technique for order preference by similarity to ideal solution(TOPSIS).Methods:Totally 18 batches of Wumei(mume fructus)were collected.The contents of gallic acid,chlorogenic acid,caffeic acid,ferulic acid,quercetin,kaempferol,malic acid,citric acid,oleanolic acid,ursolic acid,[β-sitosterol,and stigmasterol were determined by high-performance liquid chromatography(HPLC).Additionally,water-soluble extracts,total ash,and acid-insoluble ash were measured.The 15 indicators were analyzed using chemometric methods to identify quality markers.Weighted TOPSIS was applied for quality ranking with variable importance in projection(VIP)values as weights.Results:The contents of gallic acid,chlorogenic acid,caffeic acid,ferulic acid,quercetin,kaempferol,malic acid,citric acid,oleanolic acid,ursolic acid,β-sitosterol and stigmasterol were 7.056-12.115 mg/g,0.209-0.425 mg/g,3.457-6.823 mg/g,4.832-8.102 mg/g,1.180-2.025 mg/g,1.366-3.997 mg/g,25.416-50.163 mg/g,231.643-388.386 mg/g,0.599-1.025 mg/g,3.846-10.311 mg/g,0.306-0.746 mg/g,and 0.293-0.625 mg/g,respectively.Water-soluble extracts,total ash,and acid-insoluble ash accounted for 23.066％-36.739％,1.447％-5.601％,and 0.107％-0.628％,respectively.There were significant differences in the content of 15 indicators.Principal component analysis extracted two components,with cumulative variance contribution of 88.68％,identifying citric acid,malic acid,[3-sitosterol,gallic acid and ursolic acid as key quality markers.Weighted TOPSIS ranked Wumei(mume fructus)from Sichuan,Guizhou,and Yunnan as superior.Conclusion:The integrated method combining multi-component quantification,chemometrics,and weighted TOPSIS can be used for evaluating the quality of Wumei(mume fructus)from different producing areas.关键词
乌梅/高效液相色谱法/化学计量学/加权TOPSIS法/质量差异评价Key words
Wumei(mume fructus)/high-performance liquid chromatography/chemometrics/weighted TOPSIS/quality evaluation分类
医药卫生引用本文复制引用
黄爱苹,张双,魏谭军,陈飞,唐启荣,魏旭,王春龙..基于多指标成分定量、化学计量学及加权TOPSIS模型的不同产地乌梅质量差异评价[J].中医药导报,2025,31(7):51-56,90,7.基金项目
四川省中医药管理局中医药科研专项课题(2024MS040) （2024MS040）
四川省中央引导地方科技发展专项项目(2023ZYD0283) （2023ZYD0283）
达州市科技局项目(24ZDYF0004) （24ZDYF0004）
