四川大学学报（医学版）2025，Vol.56Issue(3)：619-626,8.DOI:10.12182/20250560107
肠黏膜屏障在2型糖尿病中的作用机制及中医药干预研究进展
Role of Intestinal Mucosal Barrier in Type 2 Diabetes Mellitus and Research Progress in Chinese Medicine Interventions
摘要
Abstract
The intestinal mucosal barrier is closely associated with the occurrence and development of type 2 diabetes mellitus(T2DM).It plays an important role in maintaining the homeostasis of the internal environment and resisting pathogenic invasion by regulating the metabolic homeostasis,immune response,and microbial-host interactions in the human body.According to recent studies,intestinal mucosal barrier dysregulation may constitute a key link in the pathogenesis of T2DM.Herein,we systematically reviewed the mechanisms by which intestinal mucosal barrier damage contributes to the onset of T2DM and the latest advances in modern medical intervention strategies.We also discussed and summarized the latest research findings on using traditional Chinese medicine(TCM)to regulate the intestinal mucosal barrier in the management of T2DM.Currently,the causal relationship and mechanisms linking intestinal mucosal barrier damage to the onset of T2DM remain unclear,and systematic research on the synergistic regulatory mechanisms of approaches integrating TCM and Western medicine is lacking.The approach to manage T2DM through the integration of TCM and Western medicine can provide insights and basis from multiple aspects,such as TCM syndrome differentiation and treatment,balancing drug properties,and multi-targeted therapy.In the future,we should fully leverage the advantages of integrated TCM and Western medicine in treating T2DM and conduct in-depth research focused on the intestinal mucosal barrier,thereby informing evidence-based clinical applications.关键词
肠黏膜屏障/糖尿病,2型/中医药/肠道菌群/胰岛素抵抗Key words
Intestinal mucosal barrier/Diabetes mellitus,type 2/Medicine,Chinese traditional/Gastrointestinal microbiome/Insulin resistance引用本文复制引用
闫聪,王琪格,战丽彬..肠黏膜屏障在2型糖尿病中的作用机制及中医药干预研究进展[J].四川大学学报（医学版）,2025,56(3):619-626,8.基金项目
国家自然科学基金(No.82274377),国家中医药领军人才岐黄学者支持项目(国中医药人教函[2022]6号)和2024年辽宁中医药大学省级大学生创新创业训练计划项目(No.S202410162024)资助 （No.82274377）
