井冈山大学学报（自然科学版）2025，Vol.46Issue(4)：15-23,9.DOI:10.3969/j.issn.1674-8085.2025.04.003
雷公藤福定五环骨架的合成
SYNTHESIS OF THE PENTACYCLIC CORE OF TRIPTERIFORDIN
摘要
Abstract
The synthesis of the pentacyclic core of tripterifordin,a diterpene isolated from Tripterygium wilfordii,was reported.Notably,this compound has a complex structure,featuring a pentacyclic core and seven chiral centers,which poses considerable challenges for its synthesis.In this study,the core skeleton of tripterifordin was successfully constructed through a 16-step process involving Suzuki coupling,Heck coupling,Birch reduction,and radical cyclization.关键词
五环二萜/雷公藤福定/Heck反应/自由基环化Key words
pentacyclic diterpene/tripterifordin/heck reaction/radical cyclization分类
化学化工引用本文复制引用
张成,何冠睿,刘小宇..雷公藤福定五环骨架的合成[J].井冈山大学学报（自然科学版）,2025,46(4):15-23,9.基金项目
国家自然科学基金项目(22071161) （22071161）
四川省科技计划资助项目(2024ZYD0100) （2024ZYD0100）
