中国健康心理学杂志2025，Vol.33Issue(8)：1159-1163,5.DOI:10.13342/j.cnki.cjhp.2025.08.007
育龄期女性双相障碍躁狂发作患者治疗前后性激素水平变化及与攻击风险的相关性
Changes in sex hormone levels before and after treatment in women of reproductive age with bipolar disorder during manic episodes and their association with aggression risk
摘要
Abstract
Objective:To investigate changes in serum sex hormone levels before and after treatment in women of reproductive age with bipolar disorder(BD)during manic episodes,and to analyze their correlation with aggressive behaviors.Methods:The observation group included 58 BD patients who met the ICD-10 diagnostic criteria for ma-nic episodes and were treated at Zhengzhou Eighth People's Hospital between December 2018 and August 2020.The control group consisted of 58 healthy women of reproductive age who underwent physical examinations during the same period.Patients in the observation group received a combined treatment of magnesium valproate and quetiap-ine,and therapeutic efficacy was recorded.Serum sex hormone levels were compared between the two groups,and the correlation between serum sex hormone levels and aggressive behaviors in the observation group after 8 weeks of treatment was analyzed.Results:At baseline,serum prolactin(Prol)and testosterone(Testo)levels showed signifi-cantly elevated levels compared to the control group(P＜0.05).At baseline assessment,Pearson's r demonstrated a statistically significant positive correlation between circulating testosterone levels andproperty-directed aggressive behaviors.(r=0.411,P＜0.01).After 8 weeks of treatment,changes in serum Prol levels from baseline were posi-tively correlated with verbal aggression,property aggression,and the total Modified Overt Aggression Scale(MOAS)score(r=0.260,0.264,P＜0.05).Consistent with these findings,the variation in serum testosterone con-centrations showed positive associations with property aggression,self-directed aggression,and overall MOAS scores.(r=0.280,0.313,0.257,P＜0.05).Conclusion:Women of reproductive age with BD during manic episodes exhibit abnormal serum Prol and Testo levels;and as the treatment progresses,these patients' serum level decreaseds significantly,and their aggressiveness also decreases.关键词
双相障碍/育龄期/喹硫平/丙戊酸镁/性激素/女性/攻击行为Key words
Bipolar disorder/Reproductive age/Quetiapine/Magnesium valproate/Sex hormones/Women/Aggres-sive behavior分类
医药卫生引用本文复制引用
宋延艳,李猛,邵玉单,刘建民,王淑贤,亓晶颖,赵小会,侯瑞,付慧鹏,李峥..育龄期女性双相障碍躁狂发作患者治疗前后性激素水平变化及与攻击风险的相关性[J].中国健康心理学杂志,2025,33(8):1159-1163,5.基金项目
河南省医学科技攻关计划(联合共建)项目(编号:2018020866) （联合共建）
