检验医学与临床2025，Vol.22Issue(14)：1873-1877,1882,6.DOI:10.3969/j.issn.1672-9455.2025.14.001
TyG指数和TG/HDL-C比值预测2型糖尿病肾病合并颈动脉粥样硬化的价值
Value of TyG index and TG/HDL-C ratio in predicting type 2 diabetes nephropathy complicated with carotid atherosclerosis
摘要
Abstract
Objective To analyze the value of triglyceride glucose product(TyG)index and total triglycer-ide/high-density lipoprotein cholesterol(TG/HDL-C)ratio in predicting type 2 diabetes nephropathy(T2DN)complicated with carotid atherosclerosis(CAS).Methods A retrospective analysis was conducted on the clinical data of 196 T2DN patients admitted to Bao'an District Central Hospital.According to the intima-media thickness(IMT)of the carotid artery,they were divided into non-CAS group(IMT<1.0 mm)and CAS group(IMT≥1.0 mm).Collect and compare two sets of general data[age,gender,Body Mass Index(BMI),disease duration of T2DM and T2DN,Mogensen stage,unhealthy lifestyle habits,blood pressure and recent medication use,etc.],laboratory test indicators[fasting blood glucose(FPG),glycated hemoglobin(HbA1c),total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-den-sity lipoprotein cholesterol(HDL-C),urinary microalbumin/creatinine ratio(UACR),blood creatinine(SCr),blood uric acid(SUA)and estimated glomerular filtration rate(eGFR)],calculate TyG index and TG/HDL-C ratio.Multivariate Logistic regression was used to analysis the influencing factors of T2DN com-plicated with CAS.Receiver operating characteristic(ROC)curve was used to analysis the value of TyG index and TG/HDL-C ratio for predicting the efficacy of T2DN complicated with CAS.Results There were 62 cases(31.63%)in the non-CAS group and 134 cases(68.37%)in the CAS group.There was no statistically signif-icant difference on age,gender,BMI,the disease duration of T2DM and T2DN,Mogensen staging,unhealthy lifestyle habits,systolic blood pressure,diastolic blood pressure,lipid lowering therapy and recent medication use(P>0.05).The plasma FPG,TG levels and TyG index,TG/HDL-C ratio in the CAS group were signifi-cantly higher than those in the non-CAS group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the HbA1c,TC,LDL-C,HDL-C,UACR,SCr,SUA levels and eG-FR between the two groups(P>0.05).The results of multivariate Logistic regression analysis showed that elevated TyG index and TG/HDL-C ratio were independent risk factors for T2DN complicated with CAS(P<0.05).The ROC curve analysis results showed that the area under the curve(AUC)of TyG index pre-diction for T2DN complicated with CAS was 0.754,the cut-off value was 9.255,and the corresponding sensi-tivity and specificity were 96.91%and 41.94%respectively.The AUC of TG/HDL-C ratio predicting for T2DN complicated with CAS was 0.766 and the cut-off value was 1.515,with corresponding sensitivity and specificity of 77.32%and 67.74%respectively.Conclusion Elevated TyG index and TG/HDL-C ratio are inde-pendent risk factors for the occurrence of T2DN complicated with CAS and have certain predictive value for the occur-rence of CAS.关键词
2型糖尿病肾病/甘油三酯葡萄糖乘积指数/总甘油三酯/高密度脂蛋白胆固醇比值/颈动脉粥样硬化/相关性/预测价值Key words
type 2 diabetes nephropathy/triglyceride glucose product index/total triglyceride/high-density lipoprotein cholesterol/carotid atherosclerosis/correlation/predictive value分类
医药卫生引用本文复制引用
李娜,王雪梅,刘艳娟,邱加清,张升超..TyG指数和TG/HDL-C比值预测2型糖尿病肾病合并颈动脉粥样硬化的价值[J].检验医学与临床,2025,22(14):1873-1877,1882,6.基金项目
广东省深圳市宝安区医疗卫生科研项目(2024JD214). （2024JD214）
