检验医学与临床2025，Vol.22Issue(14)：1878-1882,5.DOI:10.3969/j.issn.1672-9455.2025.14.002
益生菌联合度拉糖肽治疗对T2DM患者肠道菌群及血清TNF-α水平的影响
Impacts of probiotics combined with dulaglutide on gut microbiota and serum tumor TNF-α level in patients with T2DM
摘要
Abstract
Objective To investigate the effect of probiotics combined with dulaglutide on gut microbiota and ser-um tumor necrosis factor-α(TNF-α)levels in patients with type 2 diabetes mellitus(T2DM).Methods A total of 148 patients with T2DM admitted to Zhangjiakou First Hospital from July 2022 to December 2023 were se-lected as the research objects,and divided into the control group and the observation group,with 74 cases in each group by the random number table method.The control group received subcutaneous injection of dulaglu-tide on the basis of routine intervention,while the observation group received Quadruple live bifidobacteria on the basis of the control group.The blood glucose indicators,insulin resistance index(HOMA-IR),intestinal flora,inflammatory factors,clinical efficacy and the occurrence of adverse reactions were compared between the two groups.Results Ultimately,exclude dropped cases,68 cases were included in the observation group and 72 cases in the control group.After treatment,the levels of fasting blood glucose(FBG),glycated hemo-globin(HbA1c),2-hour postprandial blood glucose(2 h PG),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),HOMA-IR in both groups decreased,and Enterococcus,Yeast numbers in the observation group decreased,while Bifidobacterium and Lactobacillus numbers increased,the differences were statistically signifi-cant(P<0.05).The levels of FBG,HbA1c,2-hour PG,IL-6,TNF-α,HOMA-IR,Enterococcus and Yeast numbers in the observation group were significantly lower than those in the control group,while Bifidobacteri-um and Lactobacillus numbers were significantly higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the total effective rate of the observation group(95.59%)was significantly higher than that of the control group(76.39%),and the rate of adverse reactions in the ob-servation group(4.41%)was significantly lower than that in the control group(15.28%),the differences were statistically significant(P<0.05).Conclusion The combination of probiotics combined with dulaglu-tide can improve effectively the gut microbiota of T2DM patients and reduce serum TNF-α level.关键词
2型糖尿病/度拉糖肽/益生菌/肠道菌群/肿瘤坏死因子-αKey words
type 2 diabetes mellitus/dulaglutide/probiotics/gut microbiota/tumor necrosis factor-α分类
医药卫生引用本文复制引用
吴巧娟,张孟宇,田金霞..益生菌联合度拉糖肽治疗对T2DM患者肠道菌群及血清TNF-α水平的影响[J].检验医学与临床,2025,22(14):1878-1882,5.基金项目
河北省2023年度医学科学研究课题计划项目(20232063). （20232063）
