检验医学与临床2025，Vol.22Issue(14)：1883-1887,1892,6.DOI:10.3969/j.issn.1672-9455.2025.14.003
血清MDM2、METTL3在糖尿病相关白内障患者中的水平及临床意义
Serum MDM2 and METTL3 levels and their clinical significance in diabetic cataract patients
摘要
Abstract
Objective To investigate the levels and clinical significance of serum murine double minute 2(MDM2)and methyltransferase 3(METTL3)in patients with diabetic cataract(DC).Methods A total of 100 DC patients admitted to Hengshui People's Hospital from January 2021 to June 2024 were selected as the DC group,and 100 patients with simple type 2 diabetes(T2DM)were selected as the simple T2DM group.DC patients were divided into primary stage(21 cases),immature stage(29 cases),mature stage(32 cases),over-ripe stage(18 cases)according to cataract staging.Additionally,100 volunteers who had come to the hospital for health check ups during the same period were selected as the healthy control group.Enzyme linked immu-nosorbent assay was used to detect the levels of serum MDM2 and METTL3.The levels of serum MDM2 and METTL3 of each group were compared.Multiple factor Logistic regression analysis was used to identify the influencing factors of DC occurrence.The efficacy of serum MDM2 and METTL3 in diagnosing DC was ana-lyzed using receiver operating characteristic(ROC)curve.Results The levels of serum MDM2 and METTL3 increased in the healthy control group,simple T2DM group and DC group in sequence,the differences were statistically significant when compared pairwise(P<0.05).The levels of serum MDM2 and METTL3 in-creased sequentially in DC patients in the primary stage,immature stage,mature stage and overripe stage,the differences were statistically significant when compared pairwise(P<0.05).The long course of T2DM and elevated levels of HbA1c,MDM2 and METTL3 were independent risk factors for DC occurrence(P<0.05).The area under the curve(AUC)for the combined detection of serum MDM2 and METTL3 in the diagnosis of DC was 0.870,which was significantly larger than the AUC for the individual diagnosis of serum MDM2 and METTL3(P<0.05).Conclusion Elevated serum levels of MDM2 and METTL3 are closely associated with the development and progression of DC.The combined measurement of serum MDM2 and METTL3 lev-els has high diagnostic efficiency for DC.关键词
糖尿病相关白内障/2型糖尿病/鼠双微体2/甲基转移酶3/诊断效能Key words
diabetic cataract/type 2 diabetes/murine double minute 2/methyltransferase 3/diag-nostic efficiency分类
医药卫生引用本文复制引用
李晓丹,梁冬梅,刘颖..血清MDM2、METTL3在糖尿病相关白内障患者中的水平及临床意义[J].检验医学与临床,2025,22(14):1883-1887,1892,6.基金项目
河北省医学科学研究课题项目(20220450). （20220450）
