检验医学与临床2025，Vol.22Issue(14)：1888-1892,5.DOI:10.3969/j.issn.1672-9455.2025.14.004
阿卡波糖、吡格列酮二甲双胍片联合治疗对2型糖尿病患者血清MCP-1、IGF-1、TNF-α和IL-6水平的影响和临床疗效
The influence of acarbose,pioglitazone-metformin tablets on the levels of serum MCP-1,IGF-1,TNF-α and IL-6 and the clinical efficacy in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the effect of acarbose combined with pioglitazone-metformin tablets on the levels of serum monocyte chemoattractant protein-1(MCP-1),insulin-like growth factor-1(IGF-1),tumor necrosis factor α(TNF-α)and interleukin-6(IL-6)in patients with type 2 diabetes mellitus(T2DM)and its clinical efficacy.Methods A total of 136 T2DM patients admitted to Taian Maternal and Child Health Hospital from May 2022 to May 2024 were selected as the study subjects.They were randomly divided into combination group and conventional group using a random number table method,with 68 patients in each group.The conventional group received oral treatment with pioglitazone-metformin tablets,while the combi-nation group received additional oral treatment with acarbose in addition to conventional treatment.Compare blood glucose,insulin related indicators,MCP-1,IGF-1,inflammatory cytokine level in the two groups before and after treatment,compared the incidence rates of adverse reactions and overall effectiveness between the two groups.Results There was no statistically significant difference in the levels of fasting blood glucose(FPG),2-hour postprandial blood glucose(2-hour PG),fasting insulin(FINS),IGF-1,MCP-1,TNF-α,IL-6 and insulin resistance index(HOMA-IR)between the two groups before treatment(P>0.05).After treat-ment,the levels of FPG,2-hour PG,FINS,MCP-1,TNF-α,IL-6 and HOMA-IR in both groups decreased sig-nificantly,and the combination group was significantly lower than the conventional group,with statistically significant differences(P<0.05).After treatment,the levels of IGF-1 increased in both groups,and the com-bination group was significantly higher than the conventional group,with statistically significant differences(P<0.05).The incidence rates of adverse reactions during treatment in the combination group and the con-ventional group were 17.65%and 13.24%respectively,with no statistically significant difference(χ2=0.507,P=0.477).The total effective rates of the combination group and the conventional group were 94.12%and 80.88%respectively,the combination group was higher than the conventional group,the difference was statistically significant(χ2=5.445,P=0.020).Conclusion The combination therapy of acarbose and pi-oglitazone-metformin tablets can effectively reduce blood glucose and insulin resistance,inhibit serum MCP-1 and inflammatory cytokine levels,increase IGF-1 level and treatment effect in T2DM patients.关键词
阿卡波糖/吡格列酮二甲双胍/2型糖尿病/胰岛素抵抗指数/空腹胰岛素Key words
acarbose/pioglitazone-metformin tablets/type 2 diabetes mellitus/insulin resistance in-dex/fasting insulin分类
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王秀芹,郑莉凡,孙青..阿卡波糖、吡格列酮二甲双胍片联合治疗对2型糖尿病患者血清MCP-1、IGF-1、TNF-α和IL-6水平的影响和临床疗效[J].检验医学与临床,2025,22(14):1888-1892,5.基金项目
2022年泰安市科技创新发展项目(2022NS276). （2022NS276）
