检验医学与临床2025，Vol.22Issue(14)：1893-1897,5.DOI:10.3969/j.issn.1672-9455.2025.14.005
清肝明目汤联合针刺治疗非增生性糖尿病性视网膜病变患者的疗效及对血清可溶性细胞间黏附因子1、分形素趋化因子的影响
Therapeutic effect of Qinggan Mingmu Decoction combined with acupuncture on non-proliferative diabetic retinopathy and its influences on serum soluble intercellular adhesion factor-1 and Fractalkine levels
摘要
Abstract
Objective To observe the therapeutic effect of Qinggan Mingmu Decoction combined with acu-puncture on non-proliferative diabetic retinopathy(NPDR)and its influences on serum soluble intercellular adhesion factor-1(sICAM-1)and Fractalkine levels.Methods A total of 99 NPDR patients with liver depres-sion and Yin deficiency and blood heat delusion admitted from April 2021 to March 2022 in Cangzhou Hospital of Integrated Traditional and Western Medicine selected as objects and were grouped into control group and experimental group.On the basis of conventional treatment,the control group was treated with acupuncture and oral comfort decoction,and the experimental group was treated with acupuncture and Qinggan Mingmu Decoction.Serum sICAM-1 and Fractalkine levels were detected by enzyme-linked immunosorbent assay(ELISA).The TCM syndrome score,vision,central foveal thickness(CFT),number of microangiomas,num-ber of bleeding points,serum sICAM-1 and Fractalkine levels were compared between the two groups before and after treatment,and the clinical effects of the two groups were analyzed.Results Before treatment,there was no significant difference on TCM syndrome scores,vision,CFT,the number of microangiomas and bleed-ing points,serum sICAM-1 and Fractalkine levels in the two groups(P>0.05).After treatment,the TCM syndrome scores,vision,CFT,the number of microangiomas and bleeding points,serum sICAM-1 and Fracta-lkine levels decreased compared to before treatment,and the lagarithmic vision in the expermental group was higher than that in the control group,other items in the experimental group were lower than those in the con-trol group,with statistically significant differences(P<0.05).The total effective rate of the experimental group was 89.58%,which was significantly higher than the control group's total effective rate of 72.92%,the difference was statistically significant(χ2=4.376,P=0.036).Conclusion Qinggan Mingmu Decoction com-bined with acupuncture can improve the TCM syndrome,vision and retinopathy of NPDR patients,reduce the serum sICAM-1 and Fractalkine levels,and has a better effect.关键词
非增生性糖尿病性视网膜病变/清肝明目汤/针刺/可溶性细胞间黏附因子1/分形素趋化因子/疗效Key words
non-proliferative diabetic retinopathy/Qinggan Mingmu Decoction/acupuncture/soluble intercellular adhesion factor-1/Fractalkine/therapeutic effect分类
医药卫生引用本文复制引用
王晓蕴,孔五宝,吴进,张忠勇,牛跃龙,陈伟,王元松,代亚芳,赵红敏,金倩倩..清肝明目汤联合针刺治疗非增生性糖尿病性视网膜病变患者的疗效及对血清可溶性细胞间黏附因子1、分形素趋化因子的影响[J].检验医学与临床,2025,22(14):1893-1897,5.基金项目
河北省中医药管理局科研计划项目(2021349). （2021349）
