检验医学与临床2025，Vol.22Issue(14)：1898-1903,6.DOI:10.3969/j.issn.1672-9455.2025.14.006
早期介入栓塞术对脑动脉瘤脑氧代谢、认知功能及血清VILIP-1、ACA、CXCL16的影响:与DSA下原位松夹术比较
Effects of early interventional embolization on cerebral oxygen metabolism,cognitive function and serum VILIP-1,ACA,CXCL16 in cerebral aneurysms:a comparison with in-situ clip release under DSA
摘要
Abstract
Objective To investigate the effect of early interventional embolization and in-situ clip release under digital subtraction angiography(DSA)in the treatment of cerebral aneurysms.Methods The clinical data of 115 patients with cerebral aneurysm in the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from January 2021 to January 2023 were collected for this study.A total of 58 patients underwent early interventional embolization and 57 patients underwent in-situ re-lease clip under DSA,and were included in the embolization group and the control group respectively.Oxygen metabolism indexes[blood oxygen difference(DajvO2),cerebral oxygen(SjvO2)and internal jugular vein ox-ygen(CjvO2)in the bulb of the int ernal carotid vein],cognitive function[Mini Mental State Examination(MMSE)],trypopsin like protein 1(VILIP-1),anti-cardiolipin antibody(ACA),CXC-type chemokine ligand 16(CXCL16)were compared.Results Compared with the control group,the embolization group had less in-traoperative bleeding,shorter operation time and hospital stay,the differences were statistically significant(P<0.05).There was no statistically significant difference in the complete occlusion rate of aneurysms in the two groups(P>0.05).The results of repeated measures ANOVA showed that there were time effect,inter group effect and interaction effect on SjvO2,CjvO2,DajvO2,MMSE scores,as well as VILIP-1,ACA and CX-CL16 levels in both groups(P<0.05).The results of one-way repeated measures ANOVA showed that at 7 days after surgery,the SjvO2,CjvO2 and MMSE scores in both groups were lower than those before surgery,while the levels of DajvO2 and serum VILIP-1,ACA and CXCL16 were higher than those before surgery,the differences were statistically significant(P<0.05).One month after surgery,the SjvO2,CjvO2 and MMSE scores in both groups were higher than those before surgery,while the levels of DajvO2 and serum VILIP-1,ACA and CXCL16 were lower than those before surgery,the differences were statistically significant(P<0.05).The results of multivariate analysis of variance showed that there was no statistically significant differ-ence on the preoperative SjvO2,CjvO2,DajvO2,MMSE scores and serum VILIP-1,ACA,CXCL16 levels be-tween the two groups(P>0.05).However,at 7 days and 1 month after surgery,the SjvO2,CjvO2 and MMSE scores in the embolization group were higher than those in the control group,while the DajvO2,serum VILIP-1,ACA and CXCL16 levels were lower than those in the control group,the differences were statistically signif-icant(P<0.05).The total incidence rate of complications in the embolization group was significantly lower than that in the control group,the difference was statistically significant(χ2=4.044,P=0.044).The progno-sis of the embolization group was significantly better than that of the control group,the difference was statisti-cally significant(U=2.236,P=0.025).Conclusion Early interventional embolization is better than DSA in improving perioperative indexes,complications,prognosis,cerebral oxygen metabolism,cognitive function and serum VILIP-1,ACA and CXCL16 expression,and can be used as a feasible treatment for cerebral aneurysms.关键词
脑动脉瘤/早期介入栓塞术/栓塞术与数字减影血管造影术/原位松夹术/脑氧代谢/认知功能Key words
cerebral aneurysm/early interventional embolization/digital subtraction angiography/in-situ clip release/cerebral oxygen metabolism/cognitive function分类
医药卫生引用本文复制引用
张雅轩,杨扬,文平,徐鹿,邓轶鑫,赵志军,张春阳..早期介入栓塞术对脑动脉瘤脑氧代谢、认知功能及血清VILIP-1、ACA、CXCL16的影响:与DSA下原位松夹术比较[J].检验医学与临床,2025,22(14):1898-1903,6.基金项目
国家自然科学基金项目(81960238,82360188). （81960238,82360188）
