检验医学与临床2025，Vol.22Issue(14)：1920-1925,6.DOI:10.3969/j.issn.1672-9455.2025.14.010
血清AFABP、NT-proBNP在慢性心力衰竭危险分层及短期预后中的评估价值
The value of serum AFABP and NT-proBNP in risk stratification and short-term prognosis evaluation of chronic heart failure
摘要
Abstract
Objective To investigate the value of serum adipocyte-type fatty acid-binding protein(AFABP)and N-terminal pro-B-type natriuretic peptide precursor(NT-proBNP)in risk stratification and short-term prognostic assessment of chronic heart failure(CHF),and to provide a reference for improving the prognosis of CHF.Methods A total of 210 patients with CHF in the Second Affiliated Hospital of Hainan Medical Uni-versity from September 2022 to September 2023 were selected as the CHF group,and another 100 healthy medical checkups in the same period were selected as the control group.The levels of serum AFABP and NT-proBNP were compared between the two groups.According to the New York Heart Association(NYHA)classification of heart function and left ventricular ejection fraction,the CHF group was divided with heart function classification and risk stratification(reserved group,critical group,reduced group).The serum AFABP and NT-proBNP levels of CHF patients with different heart function classification and risk stratifica-tion were compared,and the evaluation value of serum AFABP and NT-proBNP for risk stratification and short-term prognosis was analyzed.Results The levels of serum AFABP and NT-proBNP in the CHF group were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The levels of serum AFABP and NT-proBNP in NYHA grade Ⅱ CHF patients were lower than those in NYHA grade Ⅲ and NYHA grade Ⅳ patients,the levels of serum AFABP and NT-proBNP in NYHA grade Ⅲ CHF patients were lower than those in NYHA grade Ⅳ CHF patients,the differences were statisti-cally significant(P<0.05).The serum AFABP and NT-proBNP levels of CHF patients in the reserved group were lower than those in the critical group and the reduced group,the serum AFABP and NT-proBNP levels of CHF patients in the critical group were lower than those in the reduced group,the differences were statisti-cally significant(P<0.05).The levels of serum AFABP and NT-proBNP were positively correlated with NY-HA cardiac function grading(rs=0.669,0.721,P<0.05).The levels of serum AFABP and NT-proBNP were positively correlated with risk stratification(rs=0.662,0.713,P<0.05).The AUC of the combined assess-ment of serum AFABP and NT-proBNP for left ventricular ejection fraction<40%in CHF patients was 0.860(95%CI:0.784-0.917),with a sensitivity of 74.42%and a specificity of 82.43%(P<0.05).The AUC of serum AFABP and NT-proBNP combined evaluation for poor prognosis of CHF patients was 0.896(95%CI:0.846-0.934),which was higher than the AUC of AFABP and NT-proBNP evaluated separately(P<0.05).Conclusion The abnormal increase in serum AFABP and NT-proBNP levels in patients with CHF is closely related to NYHA functional classification and risk stratification.Combined detection has high evaluation value for risk stratification and short-term prognosis.关键词
慢性心力衰竭/脂肪细胞型脂肪酸结合蛋白/N末端B型利钠肽前体/心功能/危险分层/短期预后Key words
chronic heart failure/adipocyte-type fatty acid-binding protein/N-terminal pro-B type na-triuretic peptide precursor/cardiac function/risk stratification/short-term prognosis分类
医药卫生引用本文复制引用
王超,符秋爱,王会豪,周万任..血清AFABP、NT-proBNP在慢性心力衰竭危险分层及短期预后中的评估价值[J].检验医学与临床,2025,22(14):1920-1925,6.基金项目
海南省卫生健康行业普通科研项目(22A200088). （22A200088）
