检验医学与临床2025，Vol.22Issue(15)：2022-2025,2032,5.DOI:10.3969/j.issn.1672-9455.2025.15.002
急性生理学评分、肠道菌群、PGRN对重症肺炎患儿预后不良的预测价值
Predictive value of acute physiology score,gut microbiota and PGRN for poor prognosis in children with severe pneumonia
摘要
Abstract
Objective To analysis the value of acute physiology score(APS),gut microbiota and granule protein precursor(PGRN)in predicting poor prognosis in children with severe pneumonia.Methods A total of 128 children with severe pneumonia admitted to the hospital from February 2022 to February 2024 were se-lected as the research objects.According to the prognosis of 28 d after treatment,they were divided into out-come group and poor prognosis group.APS,the number of intestinal flora and PGRN levels were compared between the two groups.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in children with severe pneumonia,and the receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of APS,Escherichia coli,Bifidobacterium and PGRN for poor prognosis in chil-dren with severe pneumonia.Results The APS in the poor prognosis group was higher than that in the out-come group,and the number of Escherichia coli in the poor prognosis group was greater than that in the out-come group,and the number of Bifidobacterium in the poor prognosis group was less than that in the outcome group,and the serum PGRN level in the poor prognosis group was higher than that in the outcome group,and the differences were all statistically significant(P<0.05).Multivariate Logistic regression analysis showed that increased APS,the number of Escherichia coli and the level of PGRN were independent risk factors for poor prognosis in children with severe pneumonia(P<0.05),and the increased number of Bifidobacterium was a protective factor for poor prognosis in children with severe pneumonia(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of the combination of the 4 indicators in predicting the poor prognosis of children with severe pneumonia was larger than that of APS,Escherichia coli,Bifidobacterium and PGRN alone(Z=2.910,3.133,3.332,3.367;all P<0.05).Conclusion APS,Escherichia coli,Bifidobac-terium and PGRN have a good value in predicting the poor prognosis of children with severe pneumonia,and can be applied in clinical practice.关键词
重症肺炎/儿童/急性生理学评分/肠道菌群/颗粒蛋白前体/预后/预测价值Key words
severe pneumonia/children/acute physiology score/gut microbiota/granule protein precursor/prognosis/predictive value分类
医药卫生引用本文复制引用
李华,汪利群,唐甜甜,王昕,郭晓波..急性生理学评分、肠道菌群、PGRN对重症肺炎患儿预后不良的预测价值[J].检验医学与临床,2025,22(15):2022-2025,2032,5.基金项目
陕西省重点研发计划项目(2022SF-206). （2022SF-206）
