检验医学与临床2025，Vol.22Issue(15)：2044-2048,5.DOI:10.3969/j.issn.1672-9455.2025.15.006
椎板间内镜磨钻减压术对腰椎体后缘离断症患者的治疗效果
Therapeutic effect of interlaminar endoscopic grinding drill decompression in patients with posterior lumbar discectomy
摘要
Abstract
Objective To analyze the therapeutic effect of interlaminar endoscopic grinding drill decom-pression on patients with posterior lumbar discectomy(PRAS).Methods The patients who underwent tradi-tional open decompression were included in the control group,and the patients who underwent interlaminar endoscopic grinding drill decompression were included in the observation group.The propensity score was used to match 1∶1,and the patients who did not match were excluded.Finally,49 patients were included in each group.The postoperative recovery and complications of the two groups were compared.The levels of traumatic stress indicators[5-hydroxytryptamine(5-HT),norepinephrine(NE),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)],lumbar function recovery[lumbar disability index(ODI)score,low back pain visual analogue scale(VAS)score]of the two groups before operation and 3 months after operation were compared.The levels of intervertebral space height index(IHI),Cobb Angle,bone turnover markers(serum amino-terminal propeptide of type Ⅰ procollagen(PⅠNP),carboxy-terminal telopeptide of type Ⅰ collagen(CTX),osteocalcin(OST))were measured.Results The first ambulation time,postoperative bed time and hospitalization time in the observation group were shorter than those in the control group,and the total inci-dence of postoperative complications was lower than that in the control group,and the differences were statis-tically significant(P<0.05).At 3 months after operation,the serum levels of 5-HT,NE,CRP,and TNF-α,ODI,VAS score,IHI and Cobb Angle of the two groups were significantly lower than those before operation(P<0.05).At 3 months after operation,the serum levels of 5-HT,NE,CRP,TNF-α,ODI and VAS scores in the observation group were lower than those in the control group,and the differences were statistically signifi-cant(P<0.05).At 3 months after operation,the serum PⅠNP and CTX levels of the two groups were higher than those before operation,and the serum OST level was lower than that before operation,and the differences were statistically significant(P<0.05).At 3 months after operation,the serum PⅠNP and CTX levels of the observation group were higher than those of the control group,and the serum OST level was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion Interlaminar en-doscopic grinding drill decompression can effectively promote the recovery of lumbar function after PRAS,sig-nificantly improve the level of traumatic stress,imaging indicators and bone turnover markers,with good safety.关键词
椎板间内镜磨钻减压术/腰椎体后缘离断症/术后恢复/创伤应激/椎间隙高度Key words
interlaminar endoscopic grinding drill decompression/posterior lumbar discectomy/post-operative recovery/traumatic stress/height of intervertebral space分类
医药卫生引用本文复制引用
陈博,程虎,张钰昕,李龙,刘俊雄,郭一帆..椎板间内镜磨钻减压术对腰椎体后缘离断症患者的治疗效果[J].检验医学与临床,2025,22(15):2044-2048,5.基金项目
陕西省重点研发计划项目(2022SF-323). （2022SF-323）
