检验医学与临床2025，Vol.22Issue(15)：2049-2053,5.DOI:10.3969/j.issn.1672-9455.2025.15.007
血清Gal-3、HDAC3对重度首发精神分裂症的诊断价值
The diagnostic value of serum Gal-3 and HDAC3 for severe first-episode schizophrenia
摘要
Abstract
Objective To analyze the diagnostic value of serum galectin-3(Gal-3)and histone deacetylase 3(HDAC3)in severe first-episode schizophrenia(FES).Methods A total of 147 patients with FES admitted to the hospital from May 30,2023 to May 29,2024 were selected as the study group,and another 147 healthy vol-unteers without mental illness and brain injury who underwent physical examinations in the hospital during the same period were selected as the control group.According to the scores of the Positive and Negative Symptoms Scale(PANSS)and the Wisconsin Card Sorting Test(WCST)at admission for FES patients,they were divided into the mild group,the moderate group and the severe group.Pearson correlation analysis was used to analyze the correlations between the levels of Gal-3 and HDAC3 in the serum of patients with FES and the PANSS score and WCST test score.The receiver operating characteristic(ROC)curve was drawn to ana-lyze the diagnostic value of serum Gal-3 and HDAC3 for severe FES.Results The serum Gal-3 level in the study group was lower than that in the control group,and the serum HDAC3 level was higher than that in the control group,and the differences were all statistically significant(P<0.05).The serum Gal-3 level in the se-vere group was lower than that in the mild and moderate groups,which in the moderate group was lower than that in the mild group,and the differences were statistically significant(P<0.05).The serum HDAC3 level in the severe group was higher than that in the mild and moderate groups,which in the moderate group was higher than that in the mild group,and the differences were statistically significant(P<0.05).The results of Pearson correlation analysis showed that the PANSS positive symptoms,PANSS general psychopathology symptoms,PANSS total scores,the scores of the number of non-persistent errors and the number of wrong re-sponses of WCST test in patients with FES were negatively correlated with the serum Gal-3 level(P<0.05),and positively correlated with the serum HDAC3 level(P<0.05).The results of ROC curve analysis showed that the areas under the curve(AUC)of serum Gal-3 and HDAC3 alone and in combination 2 indexes for the diagnosis of severe FES were 0.756,0.763 and 0.834 respectively.The AUC of the combined diagnosis of the two indexes was greater than that of the individual diagnosis of serum Gal-3 and HDAC3(Z=3.341,3.726;both P<0.05).Conclusion Compared with healthy volunteers,the serum Gal-3 level in patients with FES is decreased,and the HDAC3 level is increased.The changes in the levels of both are closely related to the severi-ty of the disease,and the combined diagnosis of severe FES by the two has a higher efficacy.关键词
首发精神分裂症/半乳糖凝集素-3/组蛋白去乙酰化酶3/诊断价值Key words
first-episode schizophrenia/galectin-3/histone deacetylase 3/diagnostic value分类
医药卫生引用本文复制引用
高大永,甘雪,张学志,周振伟..血清Gal-3、HDAC3对重度首发精神分裂症的诊断价值[J].检验医学与临床,2025,22(15):2049-2053,5.基金项目
河北省卫生健康委员会医学科学研究课题(20191523). （20191523）
