检验医学与临床2025，Vol.22Issue(15)：2059-2065,7.DOI:10.3969/j.issn.1672-9455.2025.15.009
卵巢癌术前联合应用阴道彩色多普勒血流显像、血清肿瘤标志物在病理分型诊断及腹膜转移预测中的价值
The value of vaginal color Doppler flow imaging combined with serum tumor markers in the diagnosis of pathological classification and prediction of peritoneal metastasis of ovarian cancer before operation
摘要
Abstract
Objective To analyze the value of vaginal color Doppler flow imaging(CDFI)combined with serum tumor markers in the diagnosis of pathological classification and prediction of peritoneal metastasis of ovarian cancer before operation.Methods A total of 120 patients with ovarian cancer admitted to the Fourth People's Hospital of Hengshui from August 2021 to January 2023 were selected as the research objects,and were divided into type Ⅰ ovarian cancer group(41 cases)and type Ⅱ ovarian cancer group(79 cases)accord-ing to clinical pathology.CDFI and serum tumor markers[carbohydrate antigen(CA)125,CA199,carcinoem-bryonic antigen(CEA),alpha fetoprotein(AFP)]were detected before operation.The postoperative patholog-ical results were observed.CDFI indexes[resistance index(RI),pulsatility index(PI),ultrasound score]and serum tumor markers in patients with different clinicopathological types and International Federation of Gyne-cology and Obstetrics(FIGO)pathological stages were compared.The patients were followed up for 1 year af-ter discharge.According to the presence or absence of peritoneal metastasis,they were divided into metastasis group and non-metastasis group.Point-biscolumn correlation was used to analyze the correlation between CD-FI indexes,serum tumor markers and FIGO pathological stage of ovarian cancer patients.The receiver operat-ing characteristic(ROC)curve was used to analyze the diagnostic value of CDFI indexes and serum tumor markers for type Ⅱ ovarian cancer and the predictive efficiency for peritoneal metastasis of patients with ovar-ian cancer.Results The ultrasound score and serum levels of CA125,CA199,CEA and AFP in type Ⅰ ovarian cancer group were lower than those in type Ⅱ ovarian cancer group,RI and PI were higher than those in typeⅡ ovarian cancer group,and the differences were statistically significant(P<0.05).The ultrasound score and serum CA125,CA199,CEA and AFP levels of patients with FIGO pathological stage Ⅰ-Ⅱ ovarian cancer were lower than those of patients with FIGO pathological stage Ⅲ-Ⅳ ovarian cancer,RI and PI were higher than those of patients with FIGO pathological stage Ⅲ-Ⅳ ovarian cancer,and the differences were statistical-ly significant(P<0.05).Point-binomial correlation analysis showed that ultrasound score,serum CA125,CA199,CEA and AFP levels were positively correlated with FIGO pathological stage of ovarian cancer(P<0.05),RI and PI were negatively correlated with FIGO pathological stage of ovarian cancer(P<0.05).The ultrasound score and serum levels of CA125,CA199,CEA and AFP in the metastasis group were higher than those in the non-metastasis group,RI and PI were lower than those in the non-metastasis group,and the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of CDFI indexes combined with serum tumor markers in diagnosing type Ⅱ ovarian cancer was 0.936,and the AUC of CDFI indexes combined with serum tumor markers in predicting peritoneal metastasis of patients with ovarian cancer was 0.934.Conclusion The combination of CDFI indexes,CA125,CA199,CEA and AFP is helpful to diagnose the pathological classification of ovarian cancer before operation,and has a high predictive value for peritoneal metastasis.关键词
卵巢癌/阴道彩色多普勒血流显像/腹膜转移/糖类抗原125/糖类抗原199/癌胚抗原/甲胎蛋白Key words
ovarian cancer/vaginal color Doppler flow imaging/peritoneal metastasis/carbohydrate antigen 125/carbohydrate antigen 199/carcinoembryonic antigen/alpha-fetoprotein分类
医药卫生引用本文复制引用
王向东,王万里,闫悦婷,张婷婷,尹晓燕..卵巢癌术前联合应用阴道彩色多普勒血流显像、血清肿瘤标志物在病理分型诊断及腹膜转移预测中的价值[J].检验医学与临床,2025,22(15):2059-2065,7.基金项目
2024年度河北省医学科学研究课题(20241814). （20241814）
