精准医学杂志2025，Vol.40Issue(4)：322-325,330,5.DOI:10.13362/j.jpmed.202540088
IRGM在结直肠癌中的表达及其与患者临床病理特征和预后的关系
Expression of immune-related guanosine triphosphatase M in colorectal cancer and its association with clinicopathological features and prognosis
摘要
Abstract
Objective To investigate the expression characteristics of immune-related guanosine triphosphatase M(IR-GM)in colorectal cancer(CRC)tissue and its association with clinicopathological features and prognosis.Methods Fresh tumor tissue samples and the corresponding paracancerous normal tissue samples were collected from 16 patients who underwent radical resection for CRC in The Affiliated Hospital of Qingdao University,and RT-qPCR was used to measure the mRNA expression level of IRGM.Postoperative paraffin-embedded tumor tissue samples and the corresponding paracancerous normal tissue samples were collected from 143 CRC patients who were treated in The Affiliated Hospital of Qingdao University,and immunohistochemical stai-ning was used to measure the protein expression level of IRGM;the association of the protein expression level of IRGM with clini-copathological features and prognosis was analyzed.Results The mRNA expression level of IRGM in paracancerous normal tis-sue was significantly higher than that in CRC tumor tissue(t=2.836,P＜0.05).The protein expression level of IRGM in paracan-cerous normal tissue was also significantly higher than that in CRC tumor tissue(x2=23.738,P＜0.05).The low expression of IR-GM in CRC tumor tissue was significantly associated with lymph node metastasis and vascular tumor thrombus(x2=9.827,7.690,P＜0.05).The survival analysis showed that the expression level of IRGM had no significant correlation with overall survival rate or disease-free survival rate in CRC patients(P＞0.05).Conclusion The expression level of IRGM is significantly downregula-ted in CRC tissue;the low expression of IRGM is closely associated with lymph node metastasis and vascular tumor thrombus,while it is not significantly associated with the overall survival rate and disease-free survival rate of patients,suggesting that IRGM may become a potential target for the treatment of CRC.关键词
结直肠肿瘤/GTP结合蛋白质类/淋巴转移/肿瘤浸润/免疫组织化学/预后/病理状态,体征和症状Key words
Colorectal neoplasms/GTP-binding proteins/Lymphatic metastasis/Neoplasm invasiveness/Immunohisto-chemistry/Prognosis/Pathological conditions,signs and symptoms分类
医药卫生引用本文复制引用
李娜,冉雯雯,赵涵,邢晓明..IRGM在结直肠癌中的表达及其与患者临床病理特征和预后的关系[J].精准医学杂志,2025,40(4):322-325,330,5.基金项目
国家自然科学基金面上项目(81972329) （81972329）
