精准医学杂志2025，Vol.40Issue(4)：331-335,341,6.DOI:10.13362/j.jpmed.202540070
神经炎症、血管风险和阿尔茨海默病生物标志物之间的相关性分析
Association between neuroinflammation,vascular risk,and biomarkers in Alzheimer's disease
摘要
Abstract
Objective To investigate the association between neuroinflammation,vascular risk,and biomarkers in Alzheimer's disease(AD).Methods A total of 1 079 individuals without AD were selected as subjects from the China Alzhei-mer's Biomarker and Lifestyle study cohort,and Framingham General Cardiovascular Risk Score(FGCRS)was used to assess the vascular risk of the subjects.The multiple linear regression model was used to investigate the correlation of FGCRS with AD bio-markers in cerebrospinal fluid(CSF)(β-amyloid 42[Aβ42],β-amyloid 40[Aβ40],phosphorylated tau[P-tau],total tau[T-tau],Aβ42/Aβ40 ratio,T-tau/Aβ42 ratio,and P-tau/Aβ42 ratio],neuroinflammatory factors in CSF(soluble triggering receptor ex-pressed on myeloid cells 2[sTREM2]and progranulin[PGRN]),and peripheral blood inflammatory cells(white blood cell count[WBC],neutrophil count[NEU],lymphocyte count[LY],monocyte count[MONO],and neutrophil-to-lymphocyte ratio[NLR]).Mediation models were constructed with sTREM2 and PGRN as mediators to investigate the mediating effect of neuroin-flammatory factors between vascular risk and AD biomarkers.Results FGCRS was positively correlated with the levels of Aβ42,Aβ40,P-tau,and T-tau in CSF(β=0.066-0.242,t=2.020-7.928,P＜0.05),and it was also positively correlated with the levels of sTREM2 and PGRN in CSF and the levels of WBC,NEU,NLR,and MONO in peripheral blood(β=0.120-0.228,t=3.285-5.705,P＜0.05).PGRN and sTREM2 mediated the association between FGCRS and AD biomarkers in CSF(Aβ40,P-tau,T-tau,and Aβ42),with a mediation ratio of 26.75％-81.82％for sTREM2 and 9.66％-31.03％for PGRN.Conclusion The increase in vascular risk may influence the levels of AD biomarkers in CSF by increasing the levels of neuroinflammatory factors in CSF,thereby promoting the development and progression of AD.关键词
阿尔茨海默病/炎症/危险因素/血管风险/淀粉样蛋白/颗粒蛋白前体/血细胞计数/脑脊髓液/可溶性髓样细胞触发受体2/生物标记Key words
Alzheimer disease/Inflammation/Risk factors/Vascular risk/Amyloid/Progranulins/Blood cell count/Cerebrospinal fluid/Soluble triggering receptor expressed on myeloid cells 2/Biomarkers分类
医药卫生引用本文复制引用
陈彦明,胡禾颖,崔瑞萍,胡浩,谭辰辰,谭兰..神经炎症、血管风险和阿尔茨海默病生物标志物之间的相关性分析[J].精准医学杂志,2025,40(4):331-335,341,6.基金项目
国家自然科学基金项目(82271475) （82271475）
