兰州大学学报（医学版）2025，Vol.51Issue(6)：1-12,12.DOI:10.13885/j.issn.2097-681X.2025.06.001
间充质干细胞外囊泡:急性肺损伤的无细胞治疗策略
Mesenchymal stem cell-derived extracellular vesicle:a cell-free therapeutic strategy for acute lung injury
摘要
Abstract
Acute lung injury(ALI)and its severe form,acute respiratory distress syndrome(ARDS),are common critical conditions in clinical practice.Due to their diverse etiologies and severe conditions,more effective treatment methods are still yet to be developed.Mesenchymal stem cell-derived extracellular vesi-cles(MSC-EV)have advantages such as low immunogenicity and no tumorigenic risk,bringing hope for the treatment of ALI/ARDS.This review elaborated on the mechanisms of MSC-EV in treating ALI/ARDS from multiple aspects,including immune regulation and inflammation control,alveolar-capillary barrier,cell death regulation,microbial clearance and antiviral activity,and mitochondrial function protection.Additionally,this article summarized the application of exosome engineering strategies in improving therapeutic effects and dis-cussed the current preclinical and clinical research progress.MSC-EV provide a new breakthrough for the treatment of ALI/ARDS and have significant clinical translational value.关键词
间充质干细胞/细胞外囊泡/急性肺损伤/呼吸窘迫综合征/免疫调节/无细胞治疗/工程化策略Key words
mesenchymal stem cell/extracellular vesicle/acute lung injury/respiratory distress syndrome/im-mune regulation/cell-free therapeutic/engineering strategies分类
医药卫生引用本文复制引用
陈佳威,张惠兰..间充质干细胞外囊泡:急性肺损伤的无细胞治疗策略[J].兰州大学学报（医学版）,2025,51(6):1-12,12.基金项目
国家自然科学基金资助项目(82170081) （82170081）
华中科技大学同济医学院附属同济医院科研基金资助项目(25-2KYC13066-32) （25-2KYC13066-32）
