兰州大学学报（医学版）2025，Vol.51Issue(6)：65-71,78,8.DOI:10.13885/j.issn.2097-681X.2025.06.009
MSC-EV促进肝再生的机制及工程化增效策略研究进展
Frontiers in mechanisms of MSC-EV-promoted liver regenera-tion and engineered therapeutic enhancement strategies
摘要
Abstract
Mesenchymal stem cell(MSC)-derived extracellular vesicles(EV)are gaining prominence in liver regeneration medicine due to their natural nanocarrier properties and cell-free therapeutic potentials.These vesicles deliver bioactive molecules such as miRNA,circRNA,lipids,proteins,cytokines and growth factors,modulating hepatocyte proliferation,apoptosis and immune homeostasis.However,clinical translation is hin-dered by low targeting efficiency and cargo heterogeneity.Recent advances in bioengineering strategies to modify MSC-EV or parent cells show promise for enhancing regenerative efficacy.This review systematically summarized the mechanism of MSC-EV promoting liver regeneration and the frontier progress in engineering synergistic strategies,aiming to provide a theoretical basis and a new perspective for cell-free therapy to ulit-mately promote liver regeneration.关键词
肝再生/胞外囊泡/间充质干细胞/工程化改造/分子机制Key words
liver regeneration/extracellular vesicle/mesenchymal stem cell/engineering modification/mo-lecular mechanism分类
医药卫生引用本文复制引用
漆子飞,汪名飞,任龙飞,张磊,宋晓静,杨乐乐,张骁骉,邵毅,胡轩睿,王晓迪,李向阳,尚进..MSC-EV促进肝再生的机制及工程化增效策略研究进展[J].兰州大学学报（医学版）,2025,51(6):65-71,78,8.基金项目
甘肃省科技重大专项资助项目(22ZD6FA021-4) （22ZD6FA021-4）
甘肃省重点研发计划资助项目(23YFFA0034) （23YFFA0034）
