兰州大学学报（医学版）2025，Vol.51Issue(6)：72-78,7.DOI:10.13885/j.issn.2097-681X.2025.06.010
间充质干细胞治疗特发性肺纤维化的机遇与挑战
Mesenchymal stem cells therapy for idiopathic pulmonary fibrosis:opportunities and challenges
摘要
Abstract
Idiopathic pulmonary fibrosis(IPF)is a degenerative disease characterized by irreversible fibrosis and connective tissue deposition in the lung tissue,commonly seen in people over the age of 50.Aging,genet-ic and environmental factors can trigger epigenetic changes,leading to the damage and abnormal activation of alveolar epithelial cells,which in turn cause fibrosis and are considered key to the occurrence of IPF.Howev-er,the specific etiology and pathogenesis are not yet clear,and the prognosis of the disease is poor,with no cure currently available.Cellular therapy has become an emerging treatment strategy for a variety of diseases.Mesenchymal stem cells(MSCs),with their strong self-renewal,multidirectional differentiation potential and immune regulation capabilities,and low tumorigenic risk,are of significant clinical value and can provide a new perspective for the treatment of IPF.This paper discussed the challenges and prospects of MSCs in the treatment of IPF,providing a reference for future research.关键词
间充质干细胞/特发性肺纤维化/临床前研究/临床研究/归巢能力Key words
mesenchymal stem cells/idiopathic pulmonary fibrosis/preclinical research/clinical research/homing capacity分类
医药卫生引用本文复制引用
王芸,雷泽林..间充质干细胞治疗特发性肺纤维化的机遇与挑战[J].兰州大学学报（医学版）,2025,51(6):72-78,7.基金项目
国家自然科学基金资助项目(8196010043) （8196010043）
甘肃省自然科学基金资助项目(23JRRA1593) （23JRRA1593）
