兰州大学学报（医学版）2025，Vol.51Issue(6)：87-94,8.DOI:10.13885/j.issn.2097-681X.2025.06.012
胶质细胞在视神经脊髓炎谱系疾病神经痛中的研究进展
Progress in research on the role and mechanism of central glial cells in neuropathic pain in optic neuromyelitis spectrum diseases
摘要
Abstract
Neuromyelitis optica spectrum disorder(NMOSD)is an autoimmune disease characterized by the demyelination of the optic nerve and spinal cord.About 80%of patients are accompanied by refractory neuro-pathic pain,which seriously affects their quality of life.Central glial cells(astrocytes,microglia,etc.)activate the JAK-STAT signaling pathway by releasing pro-inflammatory factors such as interleukin-6 and tumor ne-crosis factor α,which play an important role in the progression of NMOSD pain.In this paper,the molecular mechanism of glia-mediated NMOSD and pain comorbidities was systematically reviewed,and its dynamic regulatory network analyzed,providing a theoretical basis for the development of specific analgesic therapy targeting glia cells.关键词
视神经脊髓炎谱系疾病/神经病理性疼痛/星形胶质细胞/小胶质细胞/水通道蛋白4抗体/信号通路Key words
neuromyelitis optic spectrum disorder/neuropathic pain/astrocytes/microglia/aquaporin-4 anti-body/signaling pathway分类
医药卫生引用本文复制引用
陈云娜,阚鸿姣,袁曼,张晓燕..胶质细胞在视神经脊髓炎谱系疾病神经痛中的研究进展[J].兰州大学学报（医学版）,2025,51(6):87-94,8.基金项目
甘肃省科技计划资助项目(21JR11RA003) （21JR11RA003）
兰州市科技计划资助项目(2023-zd-175) （2023-zd-175）
