临床肝胆病杂志2025，Vol.41Issue(7)：1241-1245,5.DOI:10.12449/JCH250701
胆汁淤积性肝病精准诊疗与前沿探索
Precision diagnosis and treatment of cholestatic liver disease and frontier exploration
摘要
Abstract
Cholestatic liver disease(CLD)encompasses a range of acute and chronic disorders characterized by impaired bile formation and/or flow.If left untreated,it may progress to cirrhosis and even liver failure.In recent years,with the development of molecular biology and omics technologies,the diagnosis and treatment of CLD are entering the era of precision medicine.This article reviews the advances in the diagnosis of CLD based on genetic testing and omics biomarkers and summarizes the latest studies and clinical trials on hydrophilic bile acid,FXR agonist,PPAR agonist,antibiotics,and novel molecules in targeted therapy for CLD.In the future,integrating omics data and implementing individualized diagnosis and treatment will be the main directions in precision medicine for CLD.This article aims to provide a reference for basic research and clinical translation in the field of CLD.关键词
胆汁淤积/精准医学/诊断/治疗学Key words
Cholestasis/Precision Medicine/Diagnosis/Therapeutics引用本文复制引用
张樑君,潘琼,柴进..胆汁淤积性肝病精准诊疗与前沿探索[J].临床肝胆病杂志,2025,41(7):1241-1245,5.基金项目
国家自然科学基金杰出青年基金(82325008) （82325008）
国家自然科学基金原创探索计划项目(82450104) National Natural Science Foundation of China for Outstanding Young Scholars(82325008) （82450104）
Original Exploration Program of the National Science Foundation of China(82450104) （82450104）
