临床肝胆病杂志2025，Vol.41Issue(7)：1251-1255,5.DOI:10.12449/JCH250703
胆汁淤积性肝病与门静脉高压
Cholestatic liver disease and portal hypertension
陈利 1杨长青1
作者信息
- 1. 同济大学附属同济医院消化科,上海 200065
- 折叠
摘要
Abstract
Cholestatic liver disease(CLD)is a group of rare chronic liver diseases with the core feature of biliary system damage,and the progression of CLD is often complicated by portal hypertension(PH),which significantly affects the prognosis of patients.This article systematically elaborates on the pathophysiological relationship between CLD and PH,with a focus on the core mechanisms such as bile acid toxicity,fibrosis-driven mechanisms,and vascular remodeling,and it also summarizes the comprehensive management strategy based on evidence-based medicine that integrates etiological treatment and PH intervention.Further studies are needed to analyze the CLD-PH molecular network,develop precise targeted therapies,and promote the application of artificial intelligence in disease stratification and prognosis prediction,so as to improve the clinical outcomes of patients.关键词
胆汁淤积/肝疾病/高血压,门静脉Key words
Cholestasis/Liver Diseases/Hypertension,Portal引用本文复制引用
陈利,杨长青..胆汁淤积性肝病与门静脉高压[J].临床肝胆病杂志,2025,41(7):1251-1255,5.
