临床肝胆病杂志2025，Vol.41Issue(7)：1256-1260,5.DOI:10.12449/JCH250704
炎症性肠病合并自身免疫性肝病
Inflammatory bowel disease comorbid with autoimmune liver disease
摘要
Abstract
The coexistence of inflammatory bowel disease(IBD)and autoimmune liver disease(AILD)has gained increasing attention in clinical practice,and there are significant increases in the prevalence rates of autoimmune hepatitis(AIH),primary sclerosing cholangitis(PSC),and AIH-PSC overlap syndrome among the patients with IBD.Several pathogenic mechanisms are shared between IBD and AILDs,including genetic susceptibility,dysregulation of the gut-liver axis,immune imbalance,and abnormal bile acid metabolism.The ECCO guidelines recommend that patients who are suspected of IBD and receive no treatment should undergo a series of liver function tests,including alanine aminotransferase,alkaline phosphatase,gamma-glutamyl transferase,and total serum bilirubin,as well as regular reexaminations during follow-up.While IBD-AILD patients have unique clinical features,there is still a lack of unified diagnosis and treatment guidelines for this comorbidity,and the selection of therapeutic goal often entails a careful balance between the intestinal tract and the liver,requiring interdisciplinary collaboration and combined therapies based on pathogenesis.Future research should focus on the dynamic regulatory networks of the gut-liver axis to develop innovative intervention strategies that ensure both efficacy and safety.关键词
自身免疫疾病/炎症性肠病/治疗学Key words
Autoimmune Diseases/Inflammatory Bowel Disease/Therapeutics引用本文复制引用
孙颖昊,钱家鸣..炎症性肠病合并自身免疫性肝病[J].临床肝胆病杂志,2025,41(7):1256-1260,5.基金项目
中国卫生行业科研专项基金(201502005) Health Research&Special Projects Grant of China(201502005) （201502005）
