临床肝胆病杂志2025，Vol.41Issue(7)：1261-1265,5.DOI:10.12449/JCH250705
重视对急性重症自身免疫性肝炎的诊治
Emphasizing the diagnosis and treatment of acute severe autoimmune hepatitis
连敏 1唐茹琦 1马雄2
作者信息
- 1. 上海交通大学医学院附属仁济医院消化内科/上海市消化疾病研究所,上海 200001
- 2. 上海交通大学医学院附属仁济医院消化内科/上海市消化疾病研究所,上海 200001||上海交通大学医学院附属仁济医院衰老与组织修复研究院,上海 200001
- 折叠
摘要
Abstract
At present,the diagnostic criteria for acute severe autoimmune hepatitis(AS-AIH)include acute onset,consistency with the diagnostic criteria for autoimmune hepatitis(AIH),presence of jaundice,and international normalized ratio≥1.5 at the time of diagnosis,without evidence of hepatic encephalopathy or previous liver disease.As a special subtype of AIH,AS-AIH is characterized by acute onset and rapid disease progression,and thus early diagnosis is of vital importance.Glucocorticoid therapy should be given as early as possible after diagnosis to prevent the progression to acute liver failure and reduce the risk of liver transplantation.Management of AS-AIH patients is challenging,since patients often lack typical clinical features and histological manifestations of AIH at the time of diagnosis,and early assessment of glucocorticoid response and a treatment regimen with proper doses are important for improving the prognosis of patients.关键词
肝炎,自身免疫性/糖皮质激素类/肝移植Key words
Hepatitis,Autoimmune/Glucocorticoids/Liver Transplantation引用本文复制引用
连敏,唐茹琦,马雄..重视对急性重症自身免疫性肝炎的诊治[J].临床肝胆病杂志,2025,41(7):1261-1265,5.
