临床肝胆病杂志2025，Vol.41Issue(7)：1270-1274,5.DOI:10.12449/JCH250707
原发性胆汁性胆管炎个性化诊疗策略
Personalized diagnosis and treatment strategies of primary biliary cholangitis
摘要
Abstract
At present,there are still certain problems in the diagnosis and treatment of primary biliary cholangitis(PBC),such as a low rate of early diagnosis,limitations in the selection of therapeutic drugs.For patients with atypical PBC and a normal level of alkaline phosphatase,IgM,age,and sex can be used as important indicators for the diagnosis of PBC.By shortening the cycle for evaluation,"Xi'an criteria"can facilitate early identification of patients who have a suboptimal response to ursodesoxycholic acid after 1-month treatment and allows clinicians to initiate second-line therapeutic agent.It provides significant platform in the clinical evaluation of prognostic information.Based on the optimization of existing models for prognostic evaluation,new dynamic models should be established based on serum indicators and liver stiffness to facilitate accurate prognostic assessment and active new drug research and development.关键词
原发性胆汁性胆管炎/预测/治疗学Key words
Primary Biliary Cholangitis/Forecasting/Therapeutics引用本文复制引用
郑林华,韩英..原发性胆汁性胆管炎个性化诊疗策略[J].临床肝胆病杂志,2025,41(7):1270-1274,5.基金项目
国家自然科学基金(82270551) （82270551）
陕西省创新能力支撑计划(2024RS-CXTD-79) National Natural Science Foundation of China(82270551) （2024RS-CXTD-79）
Science and Technology Innovation Team of Shaanxi Province(2024RS-CXTD-79) （2024RS-CXTD-79）
