临床肝胆病杂志2025，Vol.41Issue(7)：1275-1278,4.DOI:10.12449/JCH250708
急性肝衰竭血浆置换治疗生存获益的争议与思考
The survival benefit of plasma exchange in patients with acute liver failure:Controversies and thoughts
摘要
Abstract
Acute liver failure(ALF)is a rare but life-threatening clinical syndrome,and supportive care and liver transplantation are currently the main treatment methods for ALF.Plasma exchange(PEX),as a blood purification technique,can remove inflammatory mediators and toxins,and it is a widely used alternative therapy for liver transplantation in clinical practice.Studies have shown that PEX can alleviate inflammatory response,stabilize hemodynamics,and improve survival rate in ALF patients.However,a multicenter retrospective cohort study in the UK published in Journal of Hepatology in April 2025 showed that there was no improvement in overall survival benefit or transplantation-free survival rate in ALF patients after PEX,which has led to widespread debate in the academic world.This article reviews the advances in the application of PEX in ALF and discusses related controversial issues.关键词
肝功能衰竭,急性/血浆置换/多器官功能衰竭/肝移植Key words
Liver Failure,Acute/Plasma Exchange/Multiple Organ Failure/Liver Transplantation引用本文复制引用
杨笛,金清龙..急性肝衰竭血浆置换治疗生存获益的争议与思考[J].临床肝胆病杂志,2025,41(7):1275-1278,4.基金项目
国家自然科学基金(82170535) National Natural Science Foundation of China(82170535) （82170535）
