皮肤性病诊疗学杂志2025，Vol.32Issue(7)：476-484,9.DOI:10.3969/j.issn.1674-8468.2025.07.003
免疫检查点抑制剂输注时间与预后的关系:一项在中国黑色素瘤患者中的回顾性分析
Association between infusion timing of immune checkpoint inhibitors and outcomes:a ret-rospective analysis in Chinese melanoma patients
摘要
Abstract
Objective To determine the relationship between specific timing pattern of im-mune checkpoint inhibitor infusion and the prognosis of Chinese melanoma patients.Methods Clinical data were collected from 126 melanoma patients who received immune checkpoint inhibi-tors in Sun Yat-sen University Cancer Center between April 2015 and March 2024.Patients who received ≥ 20％ of PD-1 antibody infusions after 16:30 were assigned to the afternoon group,while those who received＜20％ of infusions after 16:30 were assigned to the morning group.Sur-vival outcomes between the two groups were compared using the log-rank test to determine statisti-cal significance.Results Among 61 patients who received adjuvant PD-1 antibody therapy,the median recurrence-free survival(RFS)was 9.10 months in the morning group and 19.57 months in the afternoon group,with no significant difference(P=0.546).The median overall survival(OS)in the afternoon group was not inferior to that in the morning group(NR vs.47.77 months,P=0.950,HR=0.98).Among 65 patients who received palliative PD-1 antibody therapy,the median progression-free survival(PFS)was 3.57 months in the morning group and 5.60 months in the afternoon group,with no statistically significant difference(P=0.260).Compared to the morning group,the afternoon group showed a significantly longer median overall survival(OS)(22.70 vs.14.40 months,P=0.047,HR=0.53).However,the analysis of prognostic factors revealed that receiving ≥20％ of PD-1 antibody infusions in the afternoon was not an independent risk factor for survival in this cohort.Conclusions The daily infusion timing of immune check-point inhibitors may not significantly influence survival in Chinese melanoma patients.However,multicenter prospective studies are still needed to further validate the potential chronotherapeutic effects in immunotherapy.关键词
黑色素瘤/时辰疗法/昼夜节律/中国患者/免疫检查点抑制剂/每日输注时间Key words
melanoma/chronotherapy/circadian rhythm/Chinese patients/immune checkpoint inhibitors/daily infusion time引用本文复制引用
张琼,张晓实,丁娅,李丹丹,余俊珊,吴君万,陈梓銮,张镕丞,丁秋月,陈林彬,李婧婧,文习之..免疫检查点抑制剂输注时间与预后的关系:一项在中国黑色素瘤患者中的回顾性分析[J].皮肤性病诊疗学杂志,2025,32(7):476-484,9.基金项目
国家自然科学基金(82002898) （82002898）
中国临床肿瘤学会-君实肿瘤免疫研究基金(Y-JS2019-101) （Y-JS2019-101）
