皮肤性病诊疗学杂志2025，Vol.32Issue(7)：485-491,7.DOI:10.3969/j.issn.1674-8468.2025.07.004
皮肤黑色素瘤前哨淋巴结活检中核素与非核素显像新进展
Advances in nuclear and non-nuclear imaging for sentinel lymph node biopsy in cutaneous melanoma
摘要
Abstract
Cutaneous melanoma is a highly malignant tumor,and early lymphatic metastasis significantly influences treatment decisions and prognostic evaluation.Sentinel lymph node biopsy,as a crucial technique for assessing regional lymph node involvement,has made remarkable pro-gress in recent years with the support of advanced imaging technologies.Developments in radionu-clide imaging have notably improved the accuracy of SLNB.Several novel radiotracers,such as 99mTc-Tilmanocept,have demonstrated high specificity and facilitate precise localization of senti-nel lymph nodes.Advanced imaging modalities,including single-photon emission computed tomo-graphy/computed tomography,offer accurate three-dimensional anatomical information and signifi-cantly enhance detection rates,particularly in anatomically complex regions.In addition,multi-modal imaging approaches,such as portable gamma cameras combined with lymphoscintigraphy or near-infrared fluorescence,further improve intraoperative node identification.Emerging tracers,including[68Ga]Ga-SPM and 18 F-PFPN,show promising potential in the localization and charac-terization of sentinel nodes and microscopic melanoma metastases.On the other hand,non-nuclear imaging techniques,such as multispectral optoacoustic tomography,superparamagnetic iron oxide enhanced magnetic resonance imaging,and contrast-enhanced ultrasound,have also demonstrated notable advances.This review summarizes recent progress in both nuclear and non-nuclear imaging technologies for sentinel lymph node biopsy in cutaneous melanoma,offering valuable insights for both clinicians and researchers.关键词
黑色素瘤/诊断/前哨淋巴结活检/放射性核素显像/多模态成像Key words
melanoma/diagnosis/sentinel lymph node biopsy/radionuclide imaging/multimodal imaging引用本文复制引用
邱泽群,邵国强,王焱..皮肤黑色素瘤前哨淋巴结活检中核素与非核素显像新进展[J].皮肤性病诊疗学杂志,2025,32(7):485-491,7.基金项目
国家自然科学基金(81872216) （81872216）
国家重点研究与发展计划(2022YFC2504700,2022YFC2504701,2022YFC2504705) （2022YFC2504700,2022YFC2504701,2022YFC2504705）
江苏省卫生健康委医学科研立项项目(M2024012) （M2024012）
CAMS医学科学创新基金(2024-I2M-C&T-B-089) （2024-I2M-C&T-B-089）
