摘要
Abstract
Objective To explore the effect of 1 565 nm non-ablative fractional laser com-bined with intense pulsed light on post-acne erythema and skin barrier function.Methods A to-tal of 156 patients with post acne erythema(PAE)who were treated in our hospital from March 2021 to March 2024 were screened.Patients were divided into control group(n=76)and combi-nation group(n=80)according to their willingness to the treatment.The control group received 1 565 nm non-ablative fractional laser treatment,while the combination group received additional intense pulsed light therapy on top of the control treatment.Using R software,propensity score matching was performed between the two groups using the caliper matching method at a 1∶1 ratio,resulting in 50 patients in each group.The clinical efficacy,erythema index,and skin barrier function,including transdermal water loss(TE WL),pH,a value,lactate acid sting test score,protein content in the tape strip,stratum corneum water content and self-satisfaction of patients were compared between the two groups after the treatment.Difference-in-differences model was used to analyze the effects of combined therapy on self-satisfaction score and erythema index.Results Two months after the treatment,the total effective rate of the combined group(98.00％)was significantly higher than that of the control group(78.00％).The erythema in-dex(185.53±36.65 vs.216.05±42.59),TEWL(18.23±3.12 vs.19.75±3.09)and a val-ue(14.98±1.83 vs.19.63±2.18),lactic acid sting test score(1.85±0.75 vs.3.28±1.10),and protein content in the tape strip(29.23±6.38 vs.35.05±7.26)were significantly lower in the combined group than in control group.In contrast,both stratum corneum water con-tent and self-satisfaction score were significantly higher in the combined group than in the controls(49.26±4.98 vs.38.32±4.82 for water content;4.63±1.75 vs.3.75±1.59 for satisfaction score.P＜0.05 for both).The results of difference-in-differences analysis showed that the in-crease in self-satisfaction scores after treatment was 1.367 points higher in the combination group than in the control group,and the reduction in erythema index was 12.167 points greater,indica-ting a significant therapeutic effect.Conclusions Following treatment with 1 565 nm non-ablative fractional laser combined with intense pulsed light,patients show a reduction in erythema index,improvement in skin barrier function and patient self-satisfaction scores.关键词
痤疮后红斑/非剥脱点阵激光/强脉冲光/皮肤屏障功能Key words
post-acne erythema/non-ablative fractional laser/intense pulsed light/skin barrier function
