彭栩健 1罗玲 1林向华 1王晓晨 1钟润锵 1蔡梦珊1
作者信息
- 1. 中山大学孙逸仙纪念医院检验科,广州 510120
- 折叠
摘要
Abstract
Objective To investigate the distribution and drug resistance analysis of pathogenic bacteria in abdominal infection after liver resection,transarterial chemoembolization(TACE)and liver transplan-tation in primary liver cancerpatients.Methods The clinical data of 158 primary liver cancer patients with abdominal infection after liver resection,TACE or liver transplantation in our hospital from Jan 2018 to May 2023 were retrospectively analyzed,to investigate their pathogenic bacteria distribution and drug resistance.Results From samples of patients with abdominal infection after liver resection,TACE,and liver transplantation,204,69,and 34 strains of pathogenic bacteria were cultured,respectively.Gram-negative bacteria accounted for 51.96%,62.32% and 52.94%;Gram-positive bacteria for 40.20%,30.43%,and 32.35%;and fungi for 7.84%,7.25%,14.71%,respectively.The most common pathogenic bacteria were Escherichia coli(14.71%),Escherichia coli(18.84%)and Klebsiella pneumoniae(11.76%)among primary liver cancer patients with abdominal infection after liver resection,TACE and liver trans-plantation.According to the results of drug susceptibility,Escherichia coli and Klebsiella pneumoniae had a high rate of resistance to Cephalosporins,Quinolones and Sulfonamides.Among Escherichia coli and Klebsiella pneumoniae,the detection rate of strains producing extended-spectrum beta-lactamases(ESBLs)were 56.8% and 27.8% and meanwhile,the detection rate of strains with carbapenem resistance were 2.3% and 16.2%.Conclusion Among the primary liver cancer patients with abdominal infection after liver resection,TACE or liver transplantation,the main pathogenic bacteria is enterobacteriaceae and the multi-drug resistance strains have a high rate of detection.While choosing the postoperative pro-phylactic antibiotics,the antibiotics which are effective to the enterobacteriaceae are the first choice.关键词
原发性肝癌/肝切除术/肝动脉化疗栓塞/肝移植/腹腔感染/病原菌/耐药性Key words
primary liver cancer/liver resection/transarterial chemoembolization/liver transplan-tation/abdominal infection/pathogenic bacteria/drug resistance分类
医药卫生
