岭南现代临床外科2025，Vol.25Issue(3)：162-167,6.DOI:10.3969/j.issn.1009-976X.2025.03.003
PCT联合腹腔引流液淀粉酶测定在结直肠癌术后肠瘘早期诊断及预后评估的意义研究
Study on the significance of PCT combined with amylase measurement of peritoneal drainage fluid in the early diagnosis and prognosis evaluation of intestinal fistula after colorectal cancer surgery
摘要
Abstract
Objective To analyze the application value of serum procalcitonin(PCT)combined with amylase measurement of peritoneal drainage fluid in the early diagnosis and prognosis evaluation of intestinal fistula after colorectal cancer surgery.Methods Patients who underwent surgical treatment for colorectal cancer at the hospital from March 2023 to October 2024 were selected for the study.Peritoneal drainage tubes were inserted post-operation,and serum PCT and amylase levels in the peritoneal drainage fluid were measured on the 1st,3rd,5th,and 7th days post-surgery.The patients were categorized into the intestinal fistula group and the non-intestinal fistula group based on the presence of an intestinal fistula,and a cohort observational study was conducted to compare and analyze the serum PCT and amylase levels in the peritoneal drainage fluid between the two groups.Results There were significant differ-ences(P<0.05)in serum PCT and amylase levels in peritoneal drainage fluid between the intestinal fistula group and the non-intestinal fistula group at different postoperative time periods.ROC curve analysis revealed that the AUC and sensitivity of the combined diagnosis of serum PCT and peritoneal drainage amylase were relatively high.There were significant differences(P<0.05)in serum PCT levels between the micro-fistula group and the non-micro-fistula group on postoperative days 1,3,5,and 7.ROC curve analysis revealed that serum PCT had an AUC of 0.907 and a sensitivity of 86.67% for predicting the prognosis of postoperative intestinal fistula in colorectal cancer.Conclusion The combined detection of amylase in peritoneal drainage fluid and serum PCT can improve the early diagnostic efficiency of postop-erative intestinal fistula in colorectal cancer,and changes in serum PCT levels can be used to evaluate the prognosis of patients.关键词
降钙素原/腹腔引流液/淀粉酶/结直肠癌/肠瘘Key words
procalcitonin/peritoneal drainage fluid/amylase/colorectal cancer/intestinal fistula分类
医药卫生引用本文复制引用
林良学,邓海梅,蔡海晶,庞绍春,邓志安,李奕廷,王冠,吴国忠..PCT联合腹腔引流液淀粉酶测定在结直肠癌术后肠瘘早期诊断及预后评估的意义研究[J].岭南现代临床外科,2025,25(3):162-167,6.基金项目
湛江市非资助科技攻关计划项目(2023B01147) （2023B01147）
