岭南现代临床外科2025，Vol.25Issue(3)：210-214,封3,6.DOI:10.3969/j.issn.1009-976X.2025.03.012
骨坏死孟德尔随机化分析研究进展
Research progress of Mendelian randomized analysis of osteonecrosis
庞印权 1杨喜诚 2赵立力3
作者信息
- 1. 承德医学院 研究生学院,河北 承德 067000
- 2. 河北医科大学研究生学院,石家庄 050000
- 3. 承德医学院附属邢台市人民医院关节骨科,河北 邢台 054000
- 折叠
摘要
Abstract
Mendelian randomization analysis is a data analysis technique used to evaluate etiological inference in epidemiological studies.It uses genetic variation strongly correlated with disease-related exposure factors as instrumental variables to evaluate the causal relationship between disease exposure factors and outcomes,aiming to reduce the interference of confounding factors and improve the accuracy of causal inference.There is a causal relationship between osteonecrosis and inflammatory cytokines,immunocyte phenotype,telomere length,intestinal flora and micronutrients,while there is no causal relationship between diabetes and osteonecrosis.This can more accurately reveal the etiology and patho-genesis of osteonecrosis in clinical practice,and provide new ideas and directions for the prevention and treatment of osteonecrosis.The literature of Mendelian randomization analysis of osteonecrosis was extensively reviewed in recent years,and the causal association between osteonecrosis and inflammatory cytokines,immunocyte phenotype,telomere length,intestinal flora,micronutrients and diabetes was analyzed and summarized.关键词
孟德尔随机化分析/骨坏死/因果关系/危险因素Key words
Mendelian randomization analysis/osteonecrosis/causality/risk factors分类
医药卫生引用本文复制引用
庞印权,杨喜诚,赵立力..骨坏死孟德尔随机化分析研究进展[J].岭南现代临床外科,2025,25(3):210-214,封3,6.
