山东科学2025，Vol.38Issue(4)：1-7,7.DOI:10.3976/j.issn.1002-4026.20240053
响应面法优化金银花中有机酸类成分提取工艺
Optimization of the extraction process for organic acid components obtained from Lonicera japonica Thunb.using response surface methodology
摘要
Abstract
The extraction rate of organic acid components was used as an indicator to investigate the effects of extraction process parameters,namely,extraction temperature,extraction time,solid-liquid ratio,and particle size on the extraction results using the water extraction method.A response surface model was established using a Box-Behnken design to optimize the extraction process parameters for organic acid components from Lonicera japonica Thunb.with temperature,time,and solid-liquid ratio as factors.Results show that the optimal extraction process for organic acid components from Lonicera japonica Thunb.comprise an extraction temperature of 72℃,an extraction time of 90 min,and a solid-liquid ratio of 1 g∶40 mL.Under these conditions,the extraction rate of organic acid components can reach 5.16%with a relative error of 0.96%compared to the theoretical value.关键词
金银花/有机酸/提取/响应面方法Key words
Lonicera japonica Thunb./organic acids/extraction/the response surface methodology分类
医药卫生引用本文复制引用
李万英,王海燕,汪慧铖,张鹏,方磊..响应面法优化金银花中有机酸类成分提取工艺[J].山东科学,2025,38(4):1-7,7.基金项目
山东省重点研发计划(2022TZXD0036) （2022TZXD0036）
山东省重点扶持区域引进急需紧缺人才项目(2023-12) （2023-12）
